T
Tetsuya Hirabayashi
Researcher at Institute of Medical Science
Publications - 31
Citations - 1575
Tetsuya Hirabayashi is an academic researcher from Institute of Medical Science. The author has contributed to research in topics: Phospholipase & Phospholipase A. The author has an hindex of 17, co-authored 27 publications receiving 1353 citations. Previous affiliations of Tetsuya Hirabayashi include Chiba University.
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Journal ArticleDOI
Recent progress in phospholipase A₂ research: from cells to animals to humans.
Makoto Murakami,Yoshitaka Taketomi,Yoshimi Miki,Hiroyasu Sato,Tetsuya Hirabayashi,Kei Yamamoto +5 more
TL;DR: This review focuses on current understanding of the emerging biological functions of PLA₂s and related enzymes, which evolved along with eicosanoid receptors when vertebrates first appeared.
Journal ArticleDOI
Regulatory mechanism and physiological role of cytosolic phospholipase A2.
TL;DR: This review discusses the essential features of cPLA2alpha regulation and addresses new insights into the functional properties of this enzyme, which has been implicated in fertility, striated muscle growth, renal concentration, postischemic brain injury, arthritis, inflammatory bone resorption, intestinal polyposis, pulmonary fibrosis, acute respiratory distress syndrome, and autoimmune encephalomyelitis.
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Identification of Novel Cytosolic Phospholipase A2s, Murine cPLA2δ, ϵ, and ζ, Which Form a Gene Cluster with cPLA2β
TL;DR: Cl cloning and characterization of novel murine cPLA2s are reported, which cluster on murine chromosome 2E5 and demonstrate a conserved domain structure of c PLA2, i.e. one C2 domain and one lipase domain.
Journal ArticleDOI
PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.
Tetsuya Hirabayashi,Tatsuki Anjo,Tatsuki Anjo,Arisa Kaneko,Arisa Kaneko,Yuuya Senoo,Akitaka Shibata,Hiroyuki Takama,Kohei Yokoyama,Yasumasa Nishito,Tomio Ono,Choji Taya,Kazuaki Muramatsu,Kiyoko Fukami,Agustí Muñoz-Garcia,Alan R. Brash,Kazutaka Ikeda,Makoto Arita,Masashi Akiyama,Makoto Murakami,Makoto Murakami +20 more
TL;DR: It is shown that PNPLA1, an enzyme expressed in differentiated keratinocytes, plays a crucial role in the biosynthesis of ω-O-acylceramide, a lipid component essential for skin barrier and may contribute to novel therapeutic strategies for treatment of epidermal barrier defects.
Journal ArticleDOI
The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
Hiroyasu Sato,Yoshitaka Taketomi,Yoshitaka Taketomi,Ayako Ushida,Yuki Isogai,Yuki Isogai,Takumi Kojima,Tetsuya Hirabayashi,Yoshimi Miki,Yoshimi Miki,Kei Yamamoto,Yasumasa Nishito,Tetsuyuki Kobayashi,Kazutaka Ikeda,Ryo Taguchi,Shuntaro Hara,Satoshi Ida,Yuji Miyamoto,Masayuki Watanabe,Hideo Baba,Keishi Miyata,Yuichi Oike,Michael H. Gelb,Makoto Murakami +23 more
TL;DR: The identification of "metabolic sPLA2s" adds this gene family to a growing list of lipolytic enzymes that act as metabolic coordinators.