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Yusuke Okuno
Researcher at Nagoya University
Publications - 226
Citations - 10174
Yusuke Okuno is an academic researcher from Nagoya University. The author has contributed to research in topics: Exome sequencing & Germline mutation. The author has an hindex of 39, co-authored 208 publications receiving 8187 citations. Previous affiliations of Yusuke Okuno include Nagoya City University & Tokai University.
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Journal ArticleDOI
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
T Haferlach,Yasunobu Nagata,Vera Grossmann,Yusuke Okuno,Ulrike Bacher,Genta Nagae,Susanne Schnittger,Masashi Sanada,Ayana Kon,Tamara Alpermann,Kenichi Yoshida,Andreas Roller,Niroshan Nadarajah,Yuichi Shiraishi,Yusuke Shiozawa,Kenichi Chiba,Hirokazu Tanaka,H P Koeffler,Hans-Ulrich Klein,Martin Dugas,Hiroyuki Aburatani,Alexander Kohlmann,Satoru Miyano,Claudia Haferlach,Wolfgang Kern,Seishi Ogawa +25 more
TL;DR: Large-scale genetic and molecular profiling of multiple target genes is invaluable for subclassification and prognostication in MDS patients.
Journal ArticleDOI
Integrated molecular analysis of clear-cell renal cell carcinoma.
Yusuke Sato,Tetsuichi Yoshizato,Yuichi Shiraishi,Shigekatsu Maekawa,Yusuke Okuno,Takumi Kamura,Teppei Shimamura,Aiko Sato-Otsubo,Genta Nagae,Hiromichi Suzuki,Yasunobu Nagata,Kenichi Yoshida,Ayana Kon,Yutaka Suzuki,Kenichi Chiba,Hiroko Tanaka,Atsushi Niida,Akihiro Fujimoto,Tatsuhiko Tsunoda,Teppei Morikawa,Daichi Maeda,Haruki Kume,Sumio Sugano,Masashi Fukayama,Hiroyuki Aburatani,Masashi Sanada,Masashi Sanada,Satoru Miyano,Yukio Homma,Seishi Ogawa,Seishi Ogawa +30 more
TL;DR: This integrated molecular analysis of clear-cell renal cell carcinoma unmasked new correlations between DNA methylation, gene mutation and/or gene expression and copy number profiles, enabling the stratification of clinical risks for patients with ccRCC.
Journal ArticleDOI
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
Mamiko Sakata-Yanagimoto,Terukazu Enami,Kenichi Yoshida,Yuichi Shiraishi,Ryohei Ishii,Yasuyuki Miyake,Hideharu Muto,Naoko Tsuyama,Aiko Sato-Otsubo,Yusuke Okuno,Seiji Sakata,Yuhei Kamada,Rie Nakamoto-Matsubara,Nguyen Bich Tran,Koji Izutsu,Yusuke Sato,Yasunori Ohta,Junichi Furuta,Seiichi Shimizu,Takuya Komeno,Yuji Sato,Takayoshi Ito,Masayuki Noguchi,Emiko Noguchi,Masashi Sanada,Kenichi Chiba,Hiroko Tanaka,Kazumi Suzukawa,Toru Nanmoku,Yuichi Hasegawa,Osamu Nureki,Satoru Miyano,Naoya Nakamura,Kengo Takeuchi,Seishi Ogawa,Shigeru Chiba +35 more
TL;DR: Impaired RHOA function in cooperation with preceding loss of TET2 function contributes to AITL-specific pathogenesis, and it is demonstrated that the Gly17Val RHOA mutant did not bind GTP and also inhibited wild-typeRHOA function.
Journal ArticleDOI
Genomic and molecular characterization of esophageal squamous cell carcinoma
De-Chen Lin,De-Chen Lin,Jia-Jie Hao,Yasunobu Nagata,Liang Xu,Li Shang,Xuan Meng,Yusuke Sato,Yusuke Okuno,Ana Maria Varela,Ling-Wen Ding,Manoj Garg,Li-Zhen Liu,Henry Yang,Dong Yin,Zhi-Zhou Shi,Yan-Yi Jiang,Wen-Yue Gu,Ting Gong,Yu Zhang,Xin Xu,Ori Kalid,Sharon Shacham,Seishi Ogawa,Ming-Rong Wang,H. Phillip Koeffler,H. Phillip Koeffler +26 more
TL;DR: The whole-exome or targeted deep sequencing of 139 paired ESCC cases and analysis of somatic copy number variations (SCNV) of over 180 ESCCs provide an important molecular foundation for understanding esophageal tumors and developing therapeutic targets.
Journal ArticleDOI
Landscape Of Genetic Lesions In 944 Patients With Myelodysplastic Syndromes
Yasunobu Nagata,Vera Grossmann,Yusuke Okuno,Ulrike Bacher,Genta Nagae,Susanne Schnittger,Yusuke Shiozawa,Ayana Kon,Tamara Alpermann,Kenichi Yoshida,Masashi Sanada,Andreas Roller,Niroshan Nadarajah,Yuichi Shiraishi,H. Phillip Koeffler,Hans-Ulrich Klein,Martin Dugas,Kenichi Chiba,Hiroko Tanaka,Alexander Kohlmann,Satoru Miyano,Claudia Haferlach,Hiroyuki Aburatani,Wolfgang Kern,Seishi Ogawa,Torsten Haferlach +25 more
TL;DR: These results demonstrated that the mutation/deletion status of a set of genes could be used as variables independent of clinical parameters to build a clinically relevant prognostic score.