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Yukiharu Hiyoshi
Researcher at Kumamoto University
Publications - 160
Citations - 3125
Yukiharu Hiyoshi is an academic researcher from Kumamoto University. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 24, co-authored 135 publications receiving 2319 citations. Previous affiliations of Yukiharu Hiyoshi include Japanese Foundation for Cancer Research & Kyushu University.
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Journal ArticleDOI
MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma.
Yukiharu Hiyoshi,Hidenobu Kamohara,Ryuichi Karashima,Nobutaka Sato,Yu Imamura,Youhei Nagai,Naoya Yoshida,Eiichiro Toyama,Naoko Hayashi,Masayuki Watanabe,Hideo Baba +10 more
TL;DR: MicroRNA-21 targets PDCD4 at the posttranscriptional level and regulates cell proliferation and invasion in esophageal squamous cell carcinoma.
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Sarcopenia Is a Negative Prognostic Factor After Curative Resection of Colorectal Cancer
Yuji Miyamoto,Yoshifumi Baba,Yasuo Sakamoto,Mayuko Ohuchi,Ryuma Tokunaga,Junji Kurashige,Yukiharu Hiyoshi,Shiro Iwagami,Naoya Yoshida,Megumi Yoshida,Masayuki Watanabe,Hideo Baba +11 more
TL;DR: Sarcopenia negatively impacts survival in patients undergoing curative resection for stage I–III CRC, and is associated with a poor prognosis, especially in young patients.
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MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma.
Junji Kurashige,Hidenobu Kamohara,Masayuki Watanabe,Yukiharu Hiyoshi,Masaaki Iwatsuki,Youhei Tanaka,Koichi Kinoshita,Seiya Saito,Yoshifumi Baba,Hideo Baba +9 more
TL;DR: miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer patients and is associated with significantly reduced cellular proliferation, and inhibition of cellular migration and invasion.
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CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer.
Daisuke Izumi,Takatsugu Ishimoto,Takatsugu Ishimoto,Keisuke Miyake,Hidetaka Sugihara,Kojiro Eto,Hiroshi Sawayama,Tadahito Yasuda,Yuki Kiyozumi,Takayoshi Kaida,Junji Kurashige,Yu Imamura,Yukiharu Hiyoshi,Masaaki Iwatsuki,Shiro Iwagami,Yoshifumi Baba,Yasuo Sakamoto,Yuji Miyamoto,Naoya Yoshida,Masayuki Watanabe,Hiroshi Takamori,Norie Araki,Patrick Tan,Hideo Baba +23 more
TL;DR: In this paper, the authors evaluated the efficacy of a CXCR4 antagonist (AMD3100) and a FAK inhibitor (PF-573,228) on the invasive ability of GC cells.
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Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma
Junji Kurashige,Masayuki Watanabe,Masaaki Iwatsuki,Kouichi Kinoshita,Seiya Saito,Yukiharu Hiyoshi,Hidenobu Kamohara,Y. Baba,K. Mimori,Hideo Baba +9 more
TL;DR: High expression of miR-223 had a significant adverse impact on the survival of ESCC patients through repression of the function of FBXW7, which is a functional downstream target of microRNA-223.