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Yoshifumi Baba
Researcher at Kumamoto University
Publications - 267
Citations - 10399
Yoshifumi Baba is an academic researcher from Kumamoto University. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 46, co-authored 237 publications receiving 8485 citations. Previous affiliations of Yoshifumi Baba include Sapporo Medical University & Harvard University.
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Journal ArticleDOI
CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
Takatsugu Ishimoto,Osamu Nagano,Toshifumi Yae,Mayumi Tamada,Takeshi Motohara,Hiroko Oshima,Masanobu Oshima,Tatsuya Ikeda,Rika Asaba,Hideki Yagi,Takashi Masuko,Takatsune Shimizu,Tomoki Ishikawa,Tomoki Ishikawa,Kazuharu Kai,Eri Takahashi,Yu Imamura,Yoshifumi Baba,Mitsuyo Ohmura,Makoto Suematsu,Hideo Baba,Hideyuki Saya +21 more
TL;DR: It is shown that a CD44 variant (CD44v) interacts with xCT, a glutamate-cystine transporter, and controls the intracellular level of reduced glutathione (GSH).
Journal ArticleDOI
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.
Xiaoyun Liao,Paul Lochhead,Reiko Nishihara,Teppei Morikawa,Aya Kuchiba,Mai Yamauchi,Yu Imamura,Zhi Rong Qian,Yoshifumi Baba,Kaori Shima,Ruifang Sun,Katsuhiko Nosho,Jeffrey A. Meyerhardt,Edward Giovannucci,Charles S. Fuchs,Andrew T. Chan,Shuji Ogino +16 more
TL;DR: The findings from this molecular pathological epidemiology study suggest that the PIK3CA mutation in colorectal cancer may serve as a predictive molecular biomarker for adjuvant aspirin therapy.
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Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review†
Katsuhiko Nosho,Yoshifumi Baba,Noriko Tanaka,Kaori Shima,Marika Hayashi,Jeffrey A. Meyerhardt,Edward Giovannucci,Edward Giovannucci,Glenn Dranoff,Charles S. Fuchs,Charles S. Fuchs,Shuji Ogino,Shuji Ogino +12 more
TL;DR: T tumour‐infiltrating CD45RO+‐cell density is a prognostic biomarker associated with longer survival of colorectal cancer patients, independent of clinical, pathological, and molecular features.
Journal ArticleDOI
Lymphocytic Reaction to Colorectal Cancer Is Associated with Longer Survival, Independent of Lymph Node Count, Microsatellite Instability, and CpG Island Methylator Phenotype
Shuji Ogino,Katsuhiko Nosho,Natsumi Irahara,Jeffrey A. Meyerhardt,Yoshifumi Baba,Kaori Shima,Jonathan N. Glickman,Cristina R. Ferrone,Mari Mino-Kenudson,Noriko Tanaka,Glenn Dranoff,Edward Giovannucci,Charles S. Fuchs +12 more
TL;DR: Lymphocytic reactions to tumor were associated with improved prognosis among colorectal cancer patients, independent of lymph node count and other clinical, pathologic, and molecular characteristics.
Journal ArticleDOI
Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis
Kensuke Yamamura,Yoshifumi Baba,Shigeki Nakagawa,Kosuke Mima,Keisuke Miyake,Kenichi Nakamura,Hiroshi Sawayama,Koichi Kinoshita,Takatsugu Ishimoto,Masaaki Iwatsuki,Yasuo Sakamoto,Yo-ichi Yamashita,Naoya Yoshida,Masayuki Watanabe,Hideo Baba +14 more
TL;DR: F. nucleatum in esophageal cancer tissues was associated with shorter survival, suggesting a potential role as a prognostic biomarker and may also contribute to aggressive tumor behavior through activation of chemokines, such as CCL20.