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Yukiko Harasawa
Researcher at Kanazawa University
Publications - 5
Citations - 111
Yukiko Harasawa is an academic researcher from Kanazawa University. The author has contributed to research in topics: Salacia reticulata & Adipocyte. The author has an hindex of 5, co-authored 5 publications receiving 98 citations. Previous affiliations of Yukiko Harasawa include Musashino University.
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Journal ArticleDOI
Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice
Tomoko Akase,Tsutomu Shimada,Yukiko Harasawa,Tomohide Akase,Yukinobu Ikeya,Yukinobu Ikeya,Eiichi Nagai,Eiichi Nagai,Seiichi Iizuka,Gojiro Nakagami,Shinji Iizaka,Hiromi Sanada,Masaki Aburada +12 more
TL;DR: It is concluded that Salacia extract has remarkable potential to prevent obesity and associated metabolic disorders including the development of metabolic syndrome.
Journal ArticleDOI
Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes.
Tsutomu Shimada,Eiichi Nagai,Eiichi Nagai,Yukiko Harasawa,Michiru Watanabe,Michiru Watanabe,Kenichi Negishi,Tomoko Akase,Tomoko Akase,Yoshimichi Sai,Ken-ichi Miyamoto,Masaki Aburada +11 more
TL;DR: In this paper, the authors investigated the mechanism of action of Salacia reticulata with special attention to the adipocytes as the tissue primarily involved in the pathology of metabolic diseases.
Journal ArticleDOI
Salacia reticulata has therapeutic effects on obesity
Tsutomu Shimada,Tsutomu Shimada,Yuichiro Nakayama,Yuichiro Nakayama,Yukiko Harasawa,Yukiko Harasawa,Hirofumi Matsui,Hiroko Kobayashi,Yoshimichi Sai,Ken-ichi Miyamoto,Shunji Tomatsu,Masaki Aburada +11 more
TL;DR: It is demonstrated that the extract of S. reticulata has therapeutic effects on obesity and metabolic disorders by enhancing lipogenesis genes and suppressing lipolysis genes through the activation of AMPKα in adipocytes.
Journal ArticleDOI
Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata.
Tsutomu Shimada,Eiichi Nagai,Eiichi Nagai,Yukiko Harasawa,Tomoko Akase,Takashi Aburada,Seiichi Iizuka,Ken-ichi Miyamoto,Masaki Aburada +8 more
TL;DR: The metabolic disease-preventing effects of S. reticulata, including the antiobesity effect, may involve suppression of differentiation and accumulation in the adipocyte precursor 3T3-L1 cells.
Journal ArticleDOI
Mechanism of decrease of oral bioavailability of cyclosporin A during immunotherapy upon coadministration of amphotericin B
Junko Ishizaki,Satsuki Ito,Mingji Jin,Tsutomu Shimada,Tamae Ishigaki,Yukiko Harasawa,Koichi Yokogawa,Akiyoshi Takami,Shinji Nakao,Ken-ichi Miyamoto +9 more
TL;DR: The findings suggest that the oral bioavailability of CyA is reduced as a result of both increased efflux transport via P‐glycoprotein in the duodenum and an increased first‐pass effect of CYP3A2‐mediated hepatic metabolic activity, induced by AMB.