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Yukimasa Takeda

Researcher at National Institutes of Health

Publications -  22
Citations -  1250

Yukimasa Takeda is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinoic acid & Receptor. The author has an hindex of 17, co-authored 19 publications receiving 1045 citations. Previous affiliations of Yukimasa Takeda include Kyushu University.

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Journal ArticleDOI

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D

Andrzej Slominski, +10 more
- 01 Jul 2014 - 
TL;DR: This study identifies a novel signaling pathway, in which 20(OH)D3 and 20,23( OH)2D3 act as antagonists or inverse agonists of RORα and RORγ, that opens new possibilities for local (skin) or systemic regulation.
Journal ArticleDOI

Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity

Anton M. Jetten, +2 more
- 25 Jan 2013 - 
TL;DR: Retinoic acid-related orphan receptors RORα and RORγ may provide novel therapeutic targets in the management of obesity and associated metabolic diseases, including hepatosteatosis, adipose tissue-associated inflammation, and insulin resistance.
Journal ArticleDOI

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

Yukimasa Takeda, +3 more
- 01 Sep 2012 - 
TL;DR: It is demonstrated that the lack of retinoic acid-related orphan receptor (ROR) γ or α expression in mice significantly reduced the peak expression level of Cry1, Bmal1, E4bp4, Rev-Erbα and Per2 in an ROR isotype- and tissue-selective manner without affecting the phase of their rhythmic expression.
Journal ArticleDOI

Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance

Hong Soon Kang, +10 more
- 01 Jan 2011 - 
TL;DR: The data reveal that TAK1 plays a critical role in the regulation of energy and lipid homeostasis, and promotes the development of metabolic syndrome.
Journal ArticleDOI

Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis

Hong Soon Kang, +9 more
- 03 May 2011 - 
TL;DR: It is demonstrated that RORα-deficient staggerer mice fed with a high-fat diet (HFD) exhibited reduced adiposity and hepatic triglyceride levels compared with wild-type littermates and were resistant to the development of hepatic steatosis, adipose-associated inflammation, and insulin resistance.