R
Raja Jothi
Researcher at National Institutes of Health
Publications - 76
Citations - 6505
Raja Jothi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 38, co-authored 74 publications receiving 5807 citations. Previous affiliations of Raja Jothi include University of Texas at Dallas.
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Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains
TL;DR: The data indicate that C TCF may play important roles in the barrier activity of insulators, and this study provides a resource for further investigation of the CTCF function in organizing chromatin in the human genome.
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Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data.
TL;DR: Using tag density as an indicator of DNA-binding affinity, it is shown that tag densities at the binding sites are a good indicator of protein–DNA binding affinity, which could be used to distinguish and characterize strong and weak binding sites.
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An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
TL;DR: These studies indicate that esBAF is an essential component of the core pluripotency transcriptional network, and might also be a critical component in the LIF and BMP signaling pathways essential for maintenance of self-renewal and pluripOTency.
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Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types
Gang Wei,Brian J. Abraham,Ryoji Yagi,Raja Jothi,Kairong Cui,Suveena Sharma,Leelavati Narlikar,Daniel Northrup,Qingsong Tang,William E. Paul,Jinfang Zhu,Keji Zhao +11 more
TL;DR: Overall, although GATA3 binding exhibited both shared and cell-specific patterns among various T cell lineages, many genes were either positively or negatively regulated by GATA2 in a cell type-specific manner, suggesting that Gata3-mediated gene regulation depends strongly on cofactors existing in different T cells.
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Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates
Nolan J. Hoffman,Benjamin L. Parker,Rima Chaudhuri,Kelsey H. Fisher-Wellman,Maximilian Kleinert,Sean J. Humphrey,Pengyi Yang,Mira Holliday,Sophie Trefely,Daniel J. Fazakerley,Jacqueline Stöckli,James G. Burchfield,Thomas E. Jensen,Raja Jothi,Bente Kiens,Jørgen F. P. Wojtaszewski,Erik A. Richter,David E. James +17 more
TL;DR: A global analysis of protein phosphorylation in human skeletal muscle biopsies from untrained healthy males before and after a single high-intensity exercise bout revealed 1,004 unique exercise-regulated phosphosites on 562 proteins, exposing the unexplored complexity of acute exercise signaling.