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Yuliya O. Kuchkovska
Researcher at Enamine Ltd
Publications - 18
Citations - 166
Yuliya O. Kuchkovska is an academic researcher from Enamine Ltd. The author has contributed to research in topics: Chemistry & Alicyclic compound. The author has an hindex of 6, co-authored 16 publications receiving 91 citations. Previous affiliations of Yuliya O. Kuchkovska include Taras Shevchenko National University of Kyiv.
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Journal ArticleDOI
Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks.
Anton V. Chernykh,Kostiantyn P. Melnykov,Kostiantyn P. Melnykov,Nataliya A. Tolmacheva,Ivan S. Kondratov,Dmytro S. Radchenko,Dmytro S. Radchenko,Constantin G. Daniliuc,Dmitriy M. Volochnyuk,Dmitriy M. Volochnyuk,Sergey V. Ryabukhin,Sergey V. Ryabukhin,Yuliya O. Kuchkovska,Yuliya O. Kuchkovska,Oleksandr O. Grygorenko,Oleksandr O. Grygorenko +15 more
TL;DR: An efficient approach to synthesis of previously unavailable 2-substituted difluorocyclobutane building blocks was developed and applied on a multigram scale and the key step included deoxofluorination of O-protected 2-(hydroxylmethyl)cyclobutanone.
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Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles.
Bohdan A. Chalyk,Bohdan A. Chalyk,Andrii Khutorianskyi,Andrii Khutorianskyi,Andrii Lysenko,Andrii Lysenko,Yulia V Fil,Yulia V Fil,Yuliya O. Kuchkovska,Yuliya O. Kuchkovska,Konstantin S. Gavrilenko,Konstantin S. Gavrilenko,Iulia Bakanovych,Iulia Bakanovych,Yurii S. Moroz,Alina O. Gorlova,Alina O. Gorlova,Oleksandr O. Grygorenko,Oleksandr O. Grygorenko +18 more
TL;DR: A facile synthetic route towards either 3- or 5-fluoroalkyl-substituted isoxazoles or pyrazoles containing an additional functionalization site was developed and applied on a multigram scale and shown by the synthesis of fluorinated Isocarboxazid and Mepiprazole analogues.
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Formyl MIDA Boronate: C1 Building Block Enables Straightforward Access to α‐Functionalized Organoboron Derivatives
Yevhen M. Ivon,Yevhen M. Ivon,Ivan V. Mazurenko,Ivan V. Mazurenko,Yuliya O. Kuchkovska,Yuliya O. Kuchkovska,Z. V. Voitenko,Oleksandr O. Grygorenko,Oleksandr O. Grygorenko +8 more
TL;DR: The developed synthetic procedures utilizing formyl MIDA boronate were demonstrated to be tolerant to diverse functional groups, which makes this reagent an advantageous C 1 building block for extending the scope of organoboron chemistry.
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The Boron‐Wittig Olefination of Aldehydes and Ketones with Bis[(pinacolato)boryl]methane: an Extended Reaction Scope
Maksym Kovalenko,Dmytro V. Yarmoliuk,Dmytro V. Yarmoliuk,Dmytro Serhiichuk,Daria Chernenko,Daria Chernenko,Vladyslav Smyrnov,Vladyslav Smyrnov,Artur Breslavskyi,Oleksandr V. Hryshchuk,Oleksandr V. Hryshchuk,Ihor Kleban,Ihor Kleban,Yuliya V. Rassukana,Yuliya V. Rassukana,Andriy V. Tymtsunik,Andriy V. Tymtsunik,Andrey A. Tolmachev,Andrey A. Tolmachev,Yuliya O. Kuchkovska,Yuliya O. Kuchkovska,Oleksandr O. Grygorenko,Oleksandr O. Grygorenko +22 more
Journal ArticleDOI
3-((Hetera)cyclobutyl)azetidines, "Stretched" Analogues of Piperidine, Piperazine, and Morpholine: Advanced Building Blocks for Drug Discovery.
Illia O. Feskov,Anton V. Chernykh,Yuliya O. Kuchkovska,Yuliya O. Kuchkovska,Constantin G. Daniliuc,Ivan S. Kondratov,Oleksandr O. Grygorenko,Oleksandr O. Grygorenko +7 more
TL;DR: Four 3-((hetera)cyclobutyl)azetidine-based isosteres of piperidine, piperazine, and morpholine were designed and synthesized on up to gram scale and confirmed their potential utility as building blocks for lead optimization programs.