Yumei Xue

TL;DR: In this article, the authors explored the mechanism of dynamic relative protein 1 and Orai1 in cardiomyocyte hypertrophy caused by high glucose (HG) and found that Zucker diabetic fat rats induced by administration of a high-fat diet develop cardiac hyper-trophy and impaired cardiac function, accompanied by the activation of mitochondrial dynamics and calcium handling pathway related proteins.

TL;DR: Results reveal that derepression of CDK6 and activation of Rb pathway contributes to the effect of attenuation of miR-1 on provoking cardiomyocyte hypertrophy.

TL;DR: Myocyte-specific enhancer factor 2D (MEF2D), which was increased in Ang-II-induced mouse hypertrophic myocardium and cardiomyocytes, was identified as a target gene of miR-92b-3p and mimic, consistent with MEF2d siRNA, inhibited cell size increase and protein expression of ANP, ACTA1 and β-MHC in Ang

TL;DR: It is demonstrated that CF secretory function and proliferation can be up‐regulated by exposure to elevated pressure, and that Smad3 may modulate CF activation induced by high hydrostatic pressure.

TL;DR: The atrial electrical remodeling induced by hyperglycemia contributed to the increased AF susceptibility in diabetic rats.