Yunjin Lee

TL;DR: The results of the present study suggest that the bodily microbiota profile is altered in Tg-APP/PS1 mice, and that blood EVs are useful for the metagenome analysis of bodily microbiota in AD.

TL;DR: It is demonstrated that mice with increased dopamine functions in the dorsal striatum via the suppression of dopamine transporter expression in substantia nigra neurons or the optogenetic stimulation of the nigro-striatal circuitry exhibited sociability deficits and repetitive behaviors relevant to ASD pathology in animal models, while these behavioral changes were blocked by a D1 receptor antagonist.

TL;DR: Overall microbiota profiles identified in the present study represented a distinctive microbiota landscape for ASD, and the utilization of urine EVs for the rapid assessment of microbiota in ASD was validated.

TL;DR: It is demonstrated that genetic or molecular disruption of an array of molecular networks centered on adenylyl cyclase type-5 (AC5 or ADCY5) in the dorsal striatum produces autistic-like behaviors and that the dorsal Striatum regulated by AC5 is a neural correlate responsible for core ASD symptoms.

TL;DR: Results indicate that RGD-containing OPN icosamer has therapeutic potential in the postischemic brain and αvβ3 integrin-mediated anti-inflammatory effect might be an underlying mechanism.