Yunxuan Jiang

TL;DR: This study demonstrated the power of GWAS for identifying common genetic variants associated with antibiotic resistance in bacteria and that rare mutations in candidate gene, identified using large genomic data sets, can also be associated with resistance phenotypes.

TL;DR: This work proposes to establish the significance of a rare-variant test via a modified permutation procedure that uses Fisher's noncentral hypergeometric distribution to generate permuted data sets with the same structure present in the actual data set such that inference is valid in the presence of confounding factors.

TL;DR: The association between SE-encoding HLA-DRB1 alleles and susceptibility to childhood-onset RA is confirmed and Genotype-specific risk estimates suggested a hierarchy of risk, with the highest risk among individuals heterozygous for S(2) /S(3P) risk alleles.

TL;DR: The results imply that researchers need to carefully match cases and controls on ancestry in order to avoid false positives caused by population structure in studies of rare variants, particularly if genome-wide data are not available.

TL;DR: In this paper, the authors investigated RA-associated variants at 5 loci in a cohort of patients with childhood-onset rheumatoid arthritis (RA) using a weighted genetic risk score (wGRS).