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Emily K. Crispell
Researcher at Emory University
Publications - 18
Citations - 844
Emily K. Crispell is an academic researcher from Emory University. The author has contributed to research in topics: Methicillin-resistant Staphylococcus aureus & Staphylococcus aureus. The author has an hindex of 13, co-authored 18 publications receiving 712 citations. Previous affiliations of Emily K. Crispell include Women & Children's Hospital of Buffalo & Yerkes National Primate Research Center.
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Journal ArticleDOI
Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae
Victor I. Band,Emily K. Crispell,Brooke A. Napier,Carmen M. Herrera,Greg K. Tharp,Kranthi Vavikolanu,Jan Pohl,Timothy D. Read,Steven E. Bosinger,Steven E. Bosinger,M. Stephen Trent,Eileen M. Burd,David S. Weiss +12 more
TL;DR: The ability of low-frequency bacterial subpopulations to contribute to clinically relevant antibiotic resistance is demonstrated, elucidating an enigmatic cause of antibiotic treatment failure and highlighting the critical need for more sensitive diagnostics.
Journal ArticleDOI
Dissecting vancomycin-intermediate resistance in staphylococcus aureus using genome-wide association.
Tauqeer Alam,Robert A. Petit,Emily K. Crispell,Emily K. Crispell,Timothy A. Thornton,Karen N. Conneely,Yunxuan Jiang,Sarah W. Satola,Sarah W. Satola,Timothy D. Read +9 more
TL;DR: This study demonstrated the power of GWAS for identifying common genetic variants associated with antibiotic resistance in bacteria and that rare mutations in candidate gene, identified using large genomic data sets, can also be associated with resistance phenotypes.
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Decline in Pneumococcal Nasopharyngeal Carriage of Vaccine Serotypes After the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine in Children in Atlanta, Georgia.
Ankita Patel Desai,Dolly Sharma,Emily K. Crispell,Wendy Baughman,Stepy Thomas,Amy Tunali,Logan K. Sherwood,April Zmitrovich,Robert C. Jerris,Sarah W. Satola,Bernard Beall,Matthew R. Moore,Shabnam Jain,Monica M. Farley +13 more
TL;DR: Introduction of PCV13 for universal infant use was associated with significant reductions in nasopharyngeal carriage of PCv13 serotypes and resistant strains, with a similar decline in penicillin nonsusceptibility.
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Antimicrobial Peptide Resistance Mechanisms of Gram-Positive Bacteria.
TL;DR: Understanding the mechanisms of AMP resistance in Gram-positive species can provide guidelines in developing and applying AMPs as therapeutics, and offer insight into the role of resistance in bacterial pathogenesis.
Journal ArticleDOI
Detection of Staphylococcus aureus Isolates with Heterogeneous Intermediate-Level Resistance to Vancomycin in the United States
Sandra S. Richter,Sarah W. Satola,Sarah W. Satola,Emily K. Crispell,Kristopher P. Heilmann,Cassie L. Dohrn,Fathollah Riahi,Andrew J. Costello,Daniel J. Diekema,Gary V. Doern +9 more
TL;DR: The data suggest that the overall prevalence of hVISA in the United States is low (0.3%) and the rates of resistance were as follows: oxacillin, 82; erythromycin, 82%; clindamycin, 73%; levofloxacin, 73; trimethoprim-sulfamethoxazole, 9%; and daptomycin, 9%.