Yurika Miyoshi

TL;DR: It is shown that genetic inactivation of DAO in mice reduces the number and size of lower motoneurons with axonal degeneration, and that suppressed DAO activity in reactive astrocytes in the reticulospinal tract, one of the major inputs to the lower mot oneurons, predominantly contributes to the d-serine increase in the mSOD1 mouse.

TL;DR: This study examined whether multiple chiral amino acids would be associated with kidney functions, comorbidities, and prognosis of chronic kidney disease (CKD) by enantioselective analyses of all d-amino acids with a micro-two-dimensional high-performance liquid chromatograph (2D-HPLC)-based analytical platform.

TL;DR: It is shown that D-Ser serves as an endogenous ligand for GluD2 to regulate long-term depression (LTD) at synapses between parallel fibers and Purkinje cells in the immature cerebellum.

TL;DR: It is shown that the mouse intestine is rich in free d-aa that are derived from the microbiota, and the microbiota induces production of d-amino acid oxidase (DAO) by intestinal epithelial cells, which secrete the enzyme into the lumen.

TL;DR: The present micro-2D-HPLC procedures are powerful tools for the determination of small amounts of D-Ser and D-Ala in mammalian samples, and the obtained results would be useful for developing novel drugs that modulate the DAO activity, such as DAO inhibitors, against neuronal diseases.