Jacek R. Wisniewski

TL;DR: Comparisons of the proteome and the transcriptome, and analysis of protein complex databases and GO categories, suggest that deep coverage of the functional transcriptome andThe proteome of a single cell type is achieved.

TL;DR: A proteomic survey of mitochondria from mouse brain, heart, kidney, and liver and combined the results with existing gene annotations produces a list of 591 mitochondrial proteins, including 163 proteins not previously associated with this organelle, which offers new insights into the biogenesis and ancestry of mammalian mitochondria.

TL;DR: A method to accurately quantify human tumor proteomes is described by combining a mixture of five stable-isotope labeling by amino acids in cell culture (SILAC)-labeled cell lines with human carcinoma tissue, which broadens the scope of SILAC-based proteomics.

TL;DR: This study describes a different approach—the use of SILAC as an internal or 'spike-in' standard—wherein SILAC is only used to produce heavy labeled reference proteins or proteomes, and the actual experiment is therefore completely decoupled from the labeling procedure.

TL;DR: The maximal transport activity (MTA) of each OATP in human liver was predicted from transport kinetics and protein quantification and the effects of a subset of inhibitors on atorvastatin uptake in vivo were predicted.