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Yury S. Polikanov
Researcher at University of Illinois at Chicago
Publications - 62
Citations - 2736
Yury S. Polikanov is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Ribosome & Transfer RNA. The author has an hindex of 24, co-authored 51 publications receiving 1897 citations. Previous affiliations of Yury S. Polikanov include Howard Hughes Medical Institute & Yale University.
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Journal ArticleDOI
Nucleosomes Can Form a Polar Barrier to Transcript Elongation by RNA Polymerase II
Vladimir A. Bondarenko,Louise M. Steele,Andrea Újvári,Daria A. Gaykalova,Olga I. Kulaeva,Yury S. Polikanov,Donal S. Luse,Vasily M. Studitsky +7 more
TL;DR: Nucleosomes uniquely positioned on high-affinity DNA sequences present a polar barrier to transcription by human and yeast RNA polymerase II (Pol II) and entry into the tetramer by Pol II facilitates further transcription, perhaps due to partial unfolding of the Tetramer from DNA.
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Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly
TL;DR: In this article, crystal structures of the Thermus thermophilus ribosome at 2.3-to 2.5-A resolution have been reported, which have enabled modeling of rRNA modifications.
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A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
TL;DR: It is proposed that, unlike earlier models, the ribosome and the A-site tRNA facilitate the deprotonation of the nucleophile through the activation of a water molecule.
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How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
TL;DR: High-resolution crystal structures suggest that RMF binding inhibits protein synthesis by preventing initial messenger RNA (mRNA) binding and that HPF and YfiA have overlapping binding sites and would both interfere with binding of mRNA, transfer RNA, and initiation factors.
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Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.
TL;DR: The modes of action of many ribosome-targeting antibiotics are described, the major resistance mechanisms developed by pathogenic bacteria are highlighted, and recent advances in structure-assisted design of new molecules are discussed.