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Dejian Zhou
Researcher at Fudan University
Publications - 4
Citations - 190
Dejian Zhou is an academic researcher from Fudan University. The author has contributed to research in topics: Enzyme & Biology. The author has an hindex of 2, co-authored 2 publications receiving 103 citations.
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Journal ArticleDOI
Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.
TL;DR: The modes of action of many ribosome-targeting antibiotics are described, the major resistance mechanisms developed by pathogenic bacteria are highlighted, and recent advances in structure-assisted design of new molecules are discussed.
Journal ArticleDOI
Structural basis for ribosome recycling by RRF and tRNA.
TL;DR: The crystal structure of a posttermination 70S ribosome complex with EF-G, RRF and two tRNAs bound reveals the active roles played by those factors in ribosomes splitting and recycling, and uncovers a missing snapshot of tRNA as it transits between the P and exit (E) sites.
Journal ArticleDOI
Structural basis for the activity and regulation of human α-ketoglutarate dehydrogenase revealed by Cryo-EM.
You Ming Zhong,Yuanzhu Gao,Dejian Zhou,Xiaomin Ma,Huan Chen,Yingjie Xu,Wen Yang,Xiangyang Ju +7 more
TL;DR: In this paper , the 2.92 Å resolution cryo-electron microscopy (EM) structure of the E1 component 2-oxoglutarate dehydrogenase (OGDH) was reported.
Posted ContentDOI
A novel DNAJ protein, TCAIM, drives proteolysis of α-ketoglutarate dehydrogenase and regulates mitochondrial metabolism.
Jiahui Wang,You Ming Zhong,Xiao-Mei Ma,Yuanzhu Gao,Dejian Zhou,Jie Wang,Yinkun Fu,Yutong Hou,Fan Shi,Yu Zhang,Yingjie Xu,Pei-pei Wang,Marcia C. Haigis,Xiangyang Ju,Wen Hua Yang +14 more
TL;DR: A novel mtHSP70 co-chaperone DNAJC protein, TCAIM, that specifically binds to the E1 subunit of α-ketoglutarate dehydrogenase (OGDH), revealing a novel mechanism by which mitochondrial metabolism could be regulated by selective degradation of an important metabolic enzyme, mediated by a DNA JC protein.