Yusuke Okuno

TL;DR: In contrast to the wild type protein, hRad52RQK/AAA and hRad521–212 mutants with impaired ability to bind hR PA protein competed with hRPA for binding to ssDNA and failed to counteract hRpa-mediated duplex destabilization highlighting the importance of hRad 52-hRPA interactions in promoting efficient DNA annealing.

TL;DR: It is proposed that phosphorylation at Y104 enhances ssDNA annealing activity of RAD52 by attenuating dsDNA binding and overcoming the inhibitory effect of ds DNA.

TL;DR: The biophysical reconstitution and analysis of the early steps in the rejection of divergent DNA sequences by the MMR machinery during recombination initiation are reported and similarities and differences in hMSH2–hMSH6 mismatch recognition and sliding-clamp formation between a D-loop recombination intermediate and linear duplex DNA are revealed.

TL;DR: The EBV tegument protein BGLF2 is encapsulated in exosomes and released by infected cells to facilitate the establishment of EBV infection as discussed by the authors , and it is released into the cytoplasm shortly after infection.

TL;DR: The EBV tegument protein BGLF2 is encapsulated in exosomes and released by infected cells to facilitate the establishment of EBV infection as discussed by the authors , and it is released into the cytoplasm shortly after infection.