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Richard Fishel
Researcher at Ohio State University
Publications - 176
Citations - 21882
Richard Fishel is an academic researcher from Ohio State University. The author has contributed to research in topics: DNA mismatch repair & DNA repair. The author has an hindex of 71, co-authored 171 publications receiving 20889 citations. Previous affiliations of Richard Fishel include University of Vermont & University of Jena.
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Journal ArticleDOI
Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability
Asad Umar,C. Richard Boland,Jonathan P. Terdiman,Sapna Syngal,Albert de la Chapelle,Josef Rüschoff,Richard Fishel,Noralane M. Lindor,Lawrence J. Burgart,Richard Hamelin,Stanley R. Hamilton,Robert A. Hiatt,Jeremy R. Jass,Annika Lindblom,Henry T. Lynch,Päivi Peltomäki,Scott D. Ramsey,Miguel A. Rodriguez-Bigas,Hans F. A. Vasen,Ernest T. Hawk,J. Carl Barrett,Andrew N. Freedman,Sudhir Srivastava +22 more
TL;DR: This commentary summarizes the Workshop presentations on HNPCC and MSI testing; presents the issues relating to the performance, specificity, and specificity of the Bethesda Guidelines; outlines the revised Bethesda Guidelines for identifying individuals at risk for H NPCC; and recommend criteria for MSI testing.
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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
Richard Fishel,Mary Kay Lescoe,M.R.S. Rao,Neal G. Copeland,Nancy A. Jenkins,Judy Garber,Michael F. Kane,Richard D. Kolodner +7 more
TL;DR: Data and reports indicating that S. cerevisiae msh2 mutations cause an instability of dinucleotide repeats like those associated with H NPCC suggest that hMSH2 is the HNPCC gene.
Journal Article
Diagnostic Microsatellite Instability: Definition and Correlation with Mismatch Repair Protein Expression
TL;DR: These studies provide a clear recommendation for the uniform use of a panel of 10 microsatellites and a definition of at least 40% instability (using these defined marker loci) in the diagnostic analysis of MSI.
Journal ArticleDOI
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
Samir Acharya,Teresa Wilson,Scott Gradia,Michael F. Kane,Shawn Guerrette,Gerald T. Marsischky,Richard D. Kolodner,Richard Fishel +7 more
TL;DR: Analysis of the mismatched nucleotide-binding specificity of the hMSH2-hMSH3 and hMSh2-HMSH6 protein complexes showed that they have overlapping but not identical binding specificity, which helps to explain the distribution of mutations in different mismatch-repair genes seen in hereditary nonpolyposis colon cancer.
Journal Article
Loss of DNA mismatch repair in acquired resistance to cisplatin.
Stefan Aebi,Buran Kurdi-Haidar,R. Gordon,Bruno Cenni,H Zheng,D Fink,R D Christen,Clement Richard Boland,Minoru Koi,Richard Fishel,Stephen B. Howell +10 more
TL;DR: To determine whether the loss of DNA mismatch repair itself contributes to cisplatin resistance, studies were carried out in isogenic pairs of cell lines proficient or defective in this function.