Showing papers by "Yuxiu Liu published in 2022"
25 citations
TL;DR: In this article , a light-mediated defluorosilylation protocol for converting α-trifluoromethyl arylalkenes and alkyl silanes into γ,γ-difluoroallylic compounds via a combination of photoredox catalysis and hydrogen atom transfer is presented.
11 citations
TL;DR: This mild, dual-catalysis method showed good functional group tolerance and a wide substrate scope and could be used for late-stage functionalization of oligopeptides, drugs, and natural products.
10 citations
TL;DR: Direct difunctionalization of olefins, which are the most commonly used compounds in organic synthesis, is a powerful tool for rapid formation of structurally complex building blocks from readily available starting mate-rials as discussed by the authors .
9 citations
TL;DR: In this article , the authors reported a method for iron-catalyzed, visible-light-induced hydrosilylation reactions of electron-deficient alkenes to produce value-added silicon compounds.
Abstract: Herein, we report a method for iron-catalyzed, visible-light-induced hydrosilylation reactions of electron-deficient alkenes to produce value-added silicon compounds. Alkenes bearing functional groups with different steric properties were suitable substrates, as were derivatives of structurally complex natural products. Mechanistic studies showed that chlorine radicals generated by iron-catalyzed ligand-to-metal charge transfer in the presence of lithium chloride promoted the formation of silyl radicals.Introduction.
9 citations
TL;DR: In this paper , the advantages, main challenges, and corresponding solution strategies of Zn-based anodes in various aqueous rechargeable ZIBs with alkaline and mild acidic electrolytes are illustrated.
Abstract: Aqueous zinc‐ion batteries (ZIBs) have attracted widespread attention due to the intrinsic features of Zn‐based anodes, mainly including high capacity, low cost, and low working potential together with high over‐potential for hydrogen evolution reaction. Aqueous ZIBs are considered to be strong competitors and substitutes for lead‐acid, nickel‐metal hydrogen, nickel‐cadmium, and even lithium‐ion batteries. Great efforts have been made in the past few years towards the issues existed in aqueous ZIBs, mainly including alkaline and mild acidic systems. In this perspective, we illustrate the advantages, the main challenges, and the corresponding solution strategies of Zn‐based anodes in various aqueous rechargeable ZIBs with alkaline and mild acidic electrolytes. Furthermore, feasible aqueous ZIBs for practical use are prospected.
7 citations
TL;DR: In this paper , a photoactivated electron donor-acceptor complex was proposed to enable the preparation of aryl xanthates and dithiocarbamates from functionalized dibenzothiophenium salts.
6 citations
TL;DR: In this paper , an iron-catalyzed, visible-light-induced alkynylation of hydrosilanes was proposed to produce value-added silicon compounds, and the results showed that the chlorine radicals generated by the ligand-to-metal charge transfer in the presence of lithium chloride promoted the formation of silyl radicals.
5 citations
TL;DR: A protocol for visible-light-induced perfluoroalkylation reactions of aryl acrylic acids that are applicable for the transformation of inexpensive raw materials to high-value chemicals is reported.
5 citations
TL;DR: Based on the broad-spectrum biological activities of echinopsine and acylhydrazones, a series of ECHS derivatives were designed, synthesized and their biological activities were evaluated for the first time as discussed by the authors .
Abstract: Based on the broad-spectrum biological activities of echinopsine and acylhydrazones, a series of echinopsine derivatives containing acylhydrazone moieties have been designed, synthesized and their biological activities were evaluated for the first time. The bioassay results indicated that most of the compounds showed moderate to good antiviral activities against tobacco mosaic virus (TMV), among which echinopsine (I) (inactivation activity, 49.5 ± 4.4%; curative activity, 46.1 ± 1.5%; protection activity, 42.6 ± 2.3%) and its derivatives 1 (inactivation activity, 44.9 ± 4.6%; curative activity, 39.8 ± 2.6%; protection activity, 47.3 ± 4.3%), 3 (inactivation activity, 47.9 ± 0.9%; curative activity, 43.7 ± 3.1%; protection activity, 44.6 ± 3.3%), 7 (inactivation activity, 46.2 ± 1.6%; curative activity, 45.0 ± 3.7%; protection activity, 41.7 ± 0.9%) showed higher anti-TMV activity in vivo at 500 mg/L than commercial ribavirin (inactivation activity, 38.9 ± 1.4%; curative activity, 39.2 ± 1.8%; protection activity, 36.4 ± 3.4%). Some compounds exhibited insecticidal activities against Plutella xylostella, Mythimna separate and Spodoptera frugiperda. Especially, compounds 7 and 27 displayed excellent insecticidal activities against Plutella xylostell (mortality 67 ± 6% and 53 ± 6%) even at 0.1 mg/L. Additionally, most echinopsine derivatives exhibited high fungicidal activities against Physalospora piricola and Sclerotinia sclerotiorum.
4 citations
TL;DR: A mild method for the deborylation deuteration of arylboronic acids with D2O, mediated by the synergistic combination of a thiol, a Lewis base, and photoredox catalysis, is reported, which showed a broad substrate scope, excellent deuterium incorporation, and functional group tolerance.
TL;DR: In this paper , a series of novel tryptophan derivatives containing azepine and acylhydrazone moieties have been designed, synthesized, characterized, and evaluated for their biological activities.
Abstract: Based on the scaffolds widely used in drug design, a series of novel tryptophan derivatives containing azepine and acylhydrazone moieties have been designed, synthesized, characterized, and evaluated for their biological activities. The bioassay results showed that the target compounds possessed moderate to good antiviral activities against the tobacco mosaic virus (TMV), among which compounds 5c, 6a, 6h, 6t, 6v, and 6y exhibited higher inactivation, curative, and protection activities in vivo than that of ribavirin (40 ± 1, 37 ± 1, 39 ± 2% at 500 mg/L). Especially, 6y showed comparable activities to that of ningnanmycin (57 ± 2, 55 ± 3, 58 ± 1% at 500 mg/L). Meanwhile, we were pleased to find that almost all these derivatives showed good larvicidal activities against Plutella xylostella. Meanwhile, these derivatives also showed a broad spectrum of fungicidal activities.
TL;DR: Wang et al. as mentioned in this paper investigated whether moving away all functional groups from the C-11 branch chain could have an impact on the bioactivities, such as anti-tobacco mosaic virus (TMV), insecticidal and fungicidal activities, a variety of N-substituted-11-butyl matrine derivatives were synthesized.
Abstract: Matrine derivatives were reported to have various biological activities, especially the ester, amide or sulfonamide derivatives of matrine deriving from the hydroxyl or carboxyl group at the end of the branch chain after the D ring of matrine is opened. In this work, to investigate whether moving away all functional groups from the C-11 branch chain could have an impact on the bioactivities, such as anti-tobacco mosaic virus (TMV), insecticidal and fungicidal activities, a variety of N-substituted-11-butyl matrine derivatives were synthesized. The obtained bioassay result showed that most N-substituted-11-butyl matrine derivatives had obviously enhanced anti-TMV activity compared with matrine, especially many compounds had good inhibitory activity close to that of commercialized virucide Ningnanmycin (inhibition rate 55.4, 57.8 ± 1.4, 55.3 ± 0.5 and 60.3 ± 1.2% at 500 μg/mL; 26.1, 29.7 ± 0.2, 24.2 ± 1.0 and 27.0 ± 0.3% at 100 μg/mL, for the in vitro activity, in vivo inactivation, curative and protection activities, respectively). Notably, N-benzoyl (7), N-benzyl (16), and N-cyclohexylmethyl-11-butyl (19) matrine derivatives had higher anti-TMV activity than Ningnanmycin at both 500 and 100 μg/mL for the four test modes, showing high potential as anti-TMV agent. Furthermore, some compounds also showed good fungicidal activity or insecticidal activity.
TL;DR: In this article , a series of 2,4-diphenyl-1,3-oxazolines containing an ether moiety at the para position of the 4-phenyl group were synthesized from different alcohols and phenols.
Abstract: To develop highly efficient and low cost acaricides, a series of 2,4-diphenyl-1,3-oxazolines containing an ether moiety at the para position of the 4-phenyl group were synthesized from different alcohols and phenols. The bioassay results showed that most of the compounds, especially the short-chain alkyl ethers, exhibited excellent acaricidal activity against both the larvae and the eggs of Tetranychus cinnabarinus. In particular, the n-propyl ether compound Ic possessed much better larvicidal activity (LC50 = 0.0015 mg/L) and ovicidal activity (LC50 = 0.0008 mg/L) than commercial acaricide etoxazole (LC50 = 0.0145 and 0.02 mg/L for larvae and eggs, respectively). In addition, some compounds also exhibited insecticidal activity, especially compound Iw (4-CF3-phenyl ether) showed higher mortality than etoxazole against Mythimna separata, Helicoverpa armigera, and Pyrausta nubilalis. Considering the high acaricidal activity and relatively low cost, Ic was worthy of further study as an acaricide agent. An alternative synthetic route for the large-scale synthesis of Ic was then studied.
TL;DR: Based on the widespread use of hydrogen bonds in drug design, a series of aldisine derivatives containing oxime, oxime ether, and hydrazone moieties were designed and synthesized, and their antiviral, larvicidal, and fungicidal activities were evaluated for the first time as discussed by the authors .
Abstract: Based on the widespread use of hydrogen bonds in drug design, a series of aldisine derivatives containing oxime, oxime ether, and hydrazone moieties were designed and synthesized, and their antiviral, larvicidal, and fungicidal activities were evaluated for the first time. The bioassay results showed that most of these derivatives were active against tobacco mosaic virus (TMV). Hydrazone derivative 12 showed in vivo inactivation, curative, and protection activities of 52 ± 4, 49 ± 1, and 52 ± 3% at 500 mg/L, which are comparable to that of the commercial antiviral drug ningnanmycin (57 ± 3, 56 ± 2, and 59 ± 1%, respectively) at the same dose. The antiviral mechanism study showed that compound 12 could cause 20S CP (coating protein) disk fusion and disintegration, thus affecting the assembly of virus particles. The result of molecular docking indicated that there were obvious hydrogen bonds between compound 12 and TMV CP. Most derivatives were active against larvae of lepidopteran pests, such as Mythimna separata, Pyrausta nubilalis, and Plutella xylostella. Some compounds also exhibited larvicidal activities against Culex pipiens; among them compounds 9 and 13 exhibited larvicidal activities of 0.81 and 1.54 mg/L (LC50), respectively. Moreover, most of the derivatives showed broad-spectrum fungicidal activities against 14 kinds of phytopathogenic fungi at 50 mg/L.
TL;DR: In this paper , an inorganophosphorus compound can modulate the oxidation potentials of alkylboronic acids so that they can act as alkyls radical precursors.
Abstract: Despite the ubiquity of alkylboronic acids in organic synthesis, their utility as alkyl radical precursors in visible-light-induced photocatalytic reactions is limited by their high oxidation potentials. In this study, we demonstrated that an inorganophosphorus compound can modulate the oxidation potentials of alkylboronic acids so that they can act as alkyl radical precursors. We propose a mechanism based on the results of fluorescence quenching experiments, electrochemical experiments, 11B and 31P NMR spectroscopy, and other techniques. In addition, we describe a simple and reliable alkylation method that has good functional group tolerance and can be used for direct C–B chlorination, cyanation, vinylation, alkynylation, and allylation, as well as late-stage functionalization of derivatized drug molecules. Notably, alkylboronic acids can be selectively activated in the presence of a boronic pinacol ester.
TL;DR: The bioassay results showed that the target compounds possessed moderate to good antiviral activities against tobacco mosaic virus (TMV), among which compounds 4, 9, 14, 19, and 24 showed higher inactivation, curative, and protection activities in vivo than that of ribavirin.
Abstract: Based on the scaffolds widely used in drug design, a series of novel tryptophan derivatives containing 2,5-diketopiperazine and acyl hydrazine moieties have been designed, synthesized, characterized, and evaluated for their biological activities. The bioassay results showed that the target compounds possessed moderate to good antiviral activities against tobacco mosaic virus (TMV), among which compounds 4, 9, 14, 19, and 24 showed higher inactivation, curative, and protection activities in vivo than that of ribavirin (39 ± 1, 37 ± 1, 39 ± 1 at 500 mg/L) and comparable to that of ningnanmycin (58 ± 1, 55 ± 1, 57 ± 1% at 500 mg/L). Thus, these compounds are a promising candidate for anti-TMV development. Most of these compounds showed broad-spectrum fungicidal activities against 13 kinds of phytopathogenic fungi and selective fungicidal activities against Alternaria solani, Phytophthora capsica, and Sclerotinia sclerotiorum. Additionally, some of these compounds exhibited larvicidal activities against Tetranychus cinnabarinus, Plutella xylostella, Culex pipiens pallens, Mythimna separata, Helicoverpa armigera, and Pyrausta nubilalis.
TL;DR: This work describes a perfectly atom-economical protocol for Smiles rearrangements without release of SO2 that does not generate C, N, or O radicals and release SO2.
TL;DR: A mild, rapid, straightforward method for visible-light-mediated sulfonamide ethylation to afford a diverse array of compounds with C(sp3)-sulfonamide skeletons to facilitate rapid structural diversification of bioactive molecules is reported.
TL;DR: The Altmetric Attention Score as discussed by the authors is a quantitative measure of the attention that a research article has received online, and it is calculated using a weighted average of the number of articles that have been published in the last few days.
Abstract: ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to “Metal-, Photocatalyst-, and Light-Free Minisci C–H Alkylation of N-Heteroarenes with Oxalates”Jianyang DongJianyang DongMore by Jianyang Dong, Zhen WangZhen WangMore by Zhen Wang, Xiaochen WangXiaochen WangMore by Xiaochen Wang, Hongjian SongHongjian SongMore by Hongjian Songhttps://orcid.org/0000-0001-7105-1196, Yuxiu LiuYuxiu LiuMore by Yuxiu Liuhttps://orcid.org/0000-0003-0462-477X, and Qingmin Wang*Qingmin WangMore by Qingmin Wanghttps://orcid.org/0000-0002-6062-3766Cite this: J. Org. Chem. 2022, 87, 22, 15719Publication Date (Web):November 7, 2022Publication History Received19 October 2022Published online7 November 2022Published inissue 18 November 2022https://doi.org/10.1021/acs.joc.2c01798Copyright © 2022 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views751Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (661 KB) Get e-Alerts Get e-Alerts
TL;DR: A mild, convenient protocol for synthesis of α-alkoxy isochroman derivatives by means of electrochemical α-C(sp3)-H/O-H cross-coupling reactions of isochromans and alcohols in the presence of benzoic acid, which facilitated the electro-oxidation process and increased the product yield.
TL;DR: A mild, robust method for synthesis of 3-acyl indoles from aldehydes by a combination of photocatalysis and palladium catalysis is reported, compatible with a wide array of functional groups and has a broad substrate scope.
TL;DR: In this paper , a series of derivatives of the marine natural product hyrtinadine A have been investigated for their antiviral and antifungal activities against 14 kinds of phytopathogenic fungi.
Abstract: Plant diseases caused by viruses and fungi have a serious impact on the quality and yield of crops, endangering food security. The use of new, green, and efficient pesticides is an important strategy to increase crop output and deal with the food crisis. Ideally, the best pesticide innovation strategy is to find and use active compounds from natural products. Here, we took the marine natural product hyrtinadine A as the lead compound, and designed, synthesized, and systematically investigated a series of its derivatives for their antiviral and antifungal activities. Compound 8a was found to have excellent antiviral activity against the tobacco mosaic virus (TMV) (inactivation inhibitory effect of 55%/500 μg/mL and 19%/100 μg/mL, curative inhibitory effect of 52%/500 μg/mL and 22%/100 μg/mL, and protection inhibitory effect of 57%/500 μg/mL and 26%/100 μg/mL) and emerged as a novel antiviral candidate. These compound derivatives displayed broad-spectrum fungicidal activities against 14 kinds of phytopathogenic fungi at 50 μg/mL and the antifungal activities of compounds 5c, 5g, 6a, and 6e against Rhizoctonia cerealis are higher than that of the commercial fungicide chlorothalonil. Therefore, this study could lay a foundation for the application of hyrtinadine A derivatives in plant protection.
TL;DR: Dong et al. as mentioned in this paper used molecular oxygen as an oxidant for photoredox minisci C-H alkylation with alkyl boronic acids.
TL;DR: A method for visible-light-induced sulfonylarylation reactions of unactivated alkenes via 1,4-(hetero)aryl migration to achieve difunctionalization ofAlkenes strategy is reported.
TL;DR: In this article , a short-chain nonionic fluorinated surfactant, designated mPEG200-TEOH-6, was developed as a novel agrochemical synergist.
TL;DR: Dong et al. as discussed by the authors proposed a visible-light mediated minisci C-H alkylation of heteroarenes with unactivated alkyl halides using O2 as an oxidant.
Abstract: Correction for ‘Visible-light-mediated Minisci C–H alkylation of heteroarenes with unactivated alkyl halides using O2 as an oxidant’ by Jianyang Dong et al., Chem. Sci., 2019, 10, 976–982, https://doi.org/10.1039/C8SC04892D.