Yuying Wang

TL;DR: Based on the recent research focus on the novel cholinesterase inhibitors with multiple bio-functions, a review aims at summarizing and discussing the most recent studies excavating the potential carbamate-based MTDLs with choline inhibition efficacy, to accelerate the pace of pleiotropic choline-based inhibitors for coping Alzheimer's disease as discussed by the authors .

TL;DR: In this paper, a series of novel N-salicyloyl tryptamine derivatives were synthesized and their anti-AD potential was evaluated both in vitro and in vivo.

TL;DR: In this article , the authors summarized the scaffold characteristics of reported non-carbamate cholinesterase inhibitors with Aβ modulation since 2020, and understand the ingenious multifunctional drug design ideas to accelerate the pace of obtaining more efficient anti-AD drugs in the future.

TL;DR: In this paper , a series of carbamate-based N-substituted tryptamine derivatives were designed and synthesized based on functional group combination strategy, and possessed both cholinesterase inhibition and neuroprotective effects.

TL;DR: In this article , the authors used affinity ultrafiltration combined with spectroscopy and molecular docking to identify novel pancreatic lipase (PL) inhibitors using affinity ultra-filtration, which can be potentially used for the development of food supplements for obesity prevention.