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Yvonne Kienast
Researcher at Hoffmann-La Roche
Publications - 19
Citations - 2797
Yvonne Kienast is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 15, co-authored 19 publications receiving 2337 citations. Previous affiliations of Yvonne Kienast include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Real-time imaging reveals the single steps of brain metastasis formation.
Yvonne Kienast,Louisa von Baumgarten,Martin Fuhrmann,Wolfgang E. F. Klinkert,Roland Goldbrunner,Jochen Herms,Frank Winkler +6 more
TL;DR: It was possible to track the fate of individual metastasizing cancer cells in vivo in relation to blood vessels deep in the mouse brain over minutes to months and provide new insights into their evolution and response to therapies.
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Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade
Martina Schmittnaegel,Nicolò Rigamonti,Ece Kadioglu,Antonino M. Cassarà,Céline Wyser Rmili,Anna Kiialainen,Yvonne Kienast,Hans-Joachim Mueller,Chia Huey Ooi,Damya Laoui,Michele De Palma +10 more
TL;DR: The authors demonstrated how inhibition of tumor angiogenesis can facilitate the access of cytotoxic T cells to tumors, while the checkpoint inhibitors protect these T cells from exhaustion, enhancing their antitumor effects.
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Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
Moritz Felcht,Robert Luck,Alexander Schering,Philipp Seidel,Kshitij Srivastava,Junhao Hu,Arne Bartol,Arne Bartol,Yvonne Kienast,Christiane Vettel,Elias K. Loos,Simone Kutschera,Simone Kutschera,Susanne Bartels,Sila Appak,Sila Appak,Eva Besemfelder,Dorothee Terhardt,Emmanouil Chavakis,Thomas Wieland,Christian Klein,Markus Thomas,Akiyoshi Uemura,Sergij Goerdt,Hellmut G. Augustin +24 more
TL;DR: A contextual model is established whereby differential TIE2 and integrin expression, binding, and activation control the role of ANG-2 in angiogenesis, and has immediate translational implications for the therapeutic exploitation of angiopoietin signaling.
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Imaging glioma cell invasion in vivo reveals mechanisms of dissemination and peritumoral angiogenesis.
Frank Winkler,Yvonne Kienast,Martin Fuhrmann,Louisa von Baumgarten,Steffen Burgold,Gerda Mitteregger,Hans A. Kretzschmar,Jochen Herms +7 more
TL;DR: Dynamic MPLSM for more than 48 h revealed that single invasive glioma cells induced intussusceptive microvascular growth and capillary loop formation, providing an explanation for their interdependence.
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Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy.
Yvonne Kienast,Christian Klein,Werner Scheuer,Romi Raemsch,Erica Lorenzon,Dirk Bernicke,Frank Herting,Sidney Yu,Laurent Martarello,Christian Gassner,Kay Stubenrauch,Kate Munro,Hellmut G. Augustin,Markus Thomas +13 more
TL;DR: Data establish Ang-2-VEGF-A CrossMab as a promising antitumor, antiangiogenic, and antimetastatic agent for the treatment of cancer.