Z
Zachary Rattner
Researcher at Yale University
Publications - 5
Citations - 1383
Zachary Rattner is an academic researcher from Yale University. The author has contributed to research in topics: Iomazenil & Cerebral blood flow. The author has an hindex of 5, co-authored 5 publications receiving 1323 citations. Previous affiliations of Zachary Rattner include Veterans Health Administration.
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Journal ArticleDOI
Computerized three‐dimensional segmented human anatomy
I. George Zubal,Charles R. Harrell,Eileen O. Smith,Zachary Rattner,Gene Gindi,Paul B. Hoffer +5 more
TL;DR: A computerized 3-dimensional volume array modeling all major internal structures of the body has been created and can serve as a voxel-based anthropomorphic phantom suitable for many computer-based modeling and simulation calculations.
Journal Article
SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms.
Anissa Abi-Dargham,Marc Laruelle,John Seibyl,Zachary Rattner,Ronald M. Baldwin,Sami S. Zoghbi,Yolanda Zea-Ponce,J. D. Bremner,T. M. Hyde,Dennis S. Charney,Paul B. Hoffer,Robert B. Innis +11 more
TL;DR: These studies demonstrated the feasibility of quantification of receptor binding with SPECT using kinetic and equilibrium methods and Iodine-125-iomazenil binding potential measured in vitro in 12 postmortem samples was found to be consistent withSPECT in vivo measurements.
Journal ArticleDOI
SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors in nonhuman primates: I. Kinetic modeling of single bolus experiments.
Marc Laruelle,Ronald M. Baldwin,Zachary Rattner,Mohammed S. Al-Tikriti,Yolanda Zea-Ponce,Sami S. Zoghbi,Dennis S. Charney,Julie C. Price,J. James Frost,Paul B. Hoffer,Robert B. Innis +10 more
TL;DR: The studies suggest the feasibility of quantitative measurement of benzodiazepine receptors by kinetic analysis of SPECT data and the inadequacy of empirical methods of analysis, such as counts ratios, to evaluate differences in receptor density.
Journal ArticleDOI
Single photon emission tomography measurement of benzodiazepine receptor number and affinity in primate brain : a constant infusion paradigm with [123I]iomazenil
Marc Laruelle,Marc Laruelle,Anissa Abi-Dargham,Anissa Abi-Dargham,Zachary Rattner,Zachary Rattner,Mohammed S. Al-Tikriti,Mohammed S. Al-Tikriti,Yolanda Zea-Ponce,Yolanda Zea-Ponce,Sami S. Zoghbi,Sami S. Zoghbi,Dennis S. Charney,Dennis S. Charney,Julie C. Price,J. James Frost,Paul B. Hoffer,Paul B. Hoffer,Ronald M. Baldwin,Ronald M. Baldwin,Robert B. Innis,Robert B. Innis +21 more
TL;DR: Benzodiazepine receptor number and affinity were measured in vivo with single photon emission tomography (SPECT) and nondisplaceable activity was measured after injection of a receptor saturating dose of flumazenil.
Journal Article
Toward absolute quantitation of cerebral blood flow using technetium-99m-HMPAO and a single scan.
TL;DR: A comparison between regional cerebral blood flow measurements obtained in human subjects using "C-methylalbumin microsphere, the CL~O~ steady-state method, and positron emission tomography" shows a clear difference in the results between the two methods.