Z
Zainab Al-Hamal
Researcher at University of Texas MD Anderson Cancer Center
Publications - 4
Citations - 520
Zainab Al-Hamal is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: T cell & Myeloid leukemia. The author has an hindex of 3, co-authored 4 publications receiving 320 citations.
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Journal ArticleDOI
Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study.
Naval Daver,Guillermo Garcia-Manero,Sreyashi Basu,Prajwal Boddu,Mansour Alfayez,Jorge E. Cortes,Marina Konopleva,Farhad Ravandi-Kashani,Elias Jabbour,Tapan M. Kadia,Graciela M. Nogueras-Gonzalez,Jing Ning,Naveen Pemmaraju,Courtney D. DiNardo,Michael Andreeff,Sherry Pierce,Tauna Gordon,Steven M. Kornblau,Wilmer Flores,Zainab Al-Hamal,Carlos E. Bueso-Ramos,Jeffrey L. Jorgensen,Keyur P. Patel,Jorge Blando,James P. Allison,Padmanee Sharma,Hagop M. Kantarjian +26 more
TL;DR: Azacitidine in combination with nivolumab therapy produced an encouraging response rate and overall survival in patients with R/R AML, particularly in HMA-naïve and salvage 1 patients.
Journal ArticleDOI
The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia
Patrick Williams,Sreyashi Basu,Guillermo Garcia-Manero,Christopher S. Hourigan,Karolyn A. Oetjen,Jorge E. Cortes,Farhad Ravandi,Elias Jabbour,Zainab Al-Hamal,Marina Konopleva,Jing Ning,Lianchun Xiao,Juliana E. Hidalgo Lopez,Steve Kornblau,Michael Andreeff,Wilmer Flores,Carlos E. Bueso-Ramos,Jorge Blando,Pallavi Galera,Katherine R. Calvo,Gheath Alatrash,James P. Allison,Hagop M. Kantarjian,Padmanee Sharma,Naval Daver +24 more
TL;DR: Phenotypic characterization of immune cells in the bone marrow of patients with acute myeloid leukemia (AML) is lacking and the need for further studies is unclear.
Journal ArticleDOI
Checkpoint Expression By Acute Myeloid Leukemia (AML) and the Immune Microenvironment Suppresses Adaptive Immunity
Patrick Williams,Sreyashi Basu,Guillermo Garcia-Manero,Jorge E. Cortes,Farhad Ravandi,Zainab Al-Hamal,Marina Konopleva,Jing Ning,Lianchun Xiao,Juliana E. Hidalgo Lopez,Steven M. Kornblau,Michael Andreeff,Wilmer Flores,Carlos E. Bueso-Ramos,Narmeen Somani,Jorge Blando,Gheath Alatrash,James P. Allison,Hagop M. Kantarjian,Padmanee Sharma,Naval Daver +20 more
TL;DR: The correlation between increased Treg infiltration, increased PD1+CD8 cells and increased PD-L1 expression on blasts in the BM indicates immune suppression at multiple levels, and the association between adverse cytogenetics and higherPD-L 1 expression on BM blasts further suggests links between AML biology and immune suppression.
Journal ArticleDOI
Treg infiltration and the expression of immune checkpoints associated with T cell exhaustion in AML.
Patrick Williams,Sreyashi Basu,Guillermo Garcia-Manero,Jorge E. Cortes,Farhad Ravandi,Elias Jabbour,Zainab Al-Hamal,Marina Konopleva,Jing Ning,Lianchun Xiao,Juliana E. Hidalgo Lopez,Steven M. Kornblau,Michael Andreeff,Carlos E. Bueso-Ramos,Jorge Blando,Gheath Alatrash,James P. Allison,Hagop M. Kantarjian,Padmanee Sharma,Naval Daver +19 more
TL;DR: The immune checkpoint landscape of Acute Myeloid Leukemia is defined to facilitate the rational selection of immune checkpoint targets and combination approaches for future celiac disease patients.