Zarana S. Patel

TL;DR: The results indicate that delivery of both growth factors may enhance bone bridging and union of the critical size defect compared to delivery of BMP-2 alone and suggests an interplay between these growth factors for early bone regeneration.

TL;DR: The results demonstrate that a systematic control of BMP-2 delivery from gelatin microparticles can be achieved by altering the extent of basic gelatin crosslinking, and that controlled release relies on enzymatic degradation of the gelatin for controlled release.

TL;DR: The dose effect of dual delivery of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) on bone regeneration was investigated in a rat cranial critical-size defect and the addition of VEGF was unable to reverse this decrease in PBF, although improvements in the number of bridged defects did occur in some groups.

TL;DR: This review will emphasize the influence of biomaterials on angiogenesis as it applies to medical device implantation, tissue engineering and therapies for pathologicalAngiogenesis.

TL;DR: The utility of gelatin microparticles and their composite scaffolds as delivery vehicles for the controlled release of VEGF for tissue engineering applications is demonstrated and kinetics were dependent on the extent of gelatin crosslinking.