P
Peng Jin
Researcher at Emory University
Publications - 250
Citations - 23698
Peng Jin is an academic researcher from Emory University. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 65, co-authored 228 publications receiving 20407 citations. Previous affiliations of Peng Jin include Hospital Research Foundation & Boston Children's Hospital.
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Journal ArticleDOI
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
Xuyu Qian,Ha Nam Nguyen,Mingxi M. Song,Christopher Hadiono,Sarah C. Ogden,Christy Hammack,Bing Yao,Gregory R. Hamersky,Fadi Jacob,Chun Zhong,Ki Jun Yoon,William J. Jeang,Li Lin,Yujing Li,Jai Thakor,Daniel A. Berg,Ce Zhang,Eunchai Kang,Michael Chickering,David W. Nauen,Cheng-Ying Ho,Cheng-Ying Ho,Zhexing Wen,Kimberly M. Christian,Pei Yong Shi,Brady J. Maher,Hao Wu,Peng Jin,Hengli Tang,Hongjun Song,Guo Li Ming +30 more
TL;DR: A miniaturized spinning bioreactor (SpinΩ) is developed to generate forebrain-specific organoids from human iPSCs that recapitulate key features of human cortical development, including progenitor zone organization, neurogenesis, gene expression, and, notably, a distinct human-specific outer radial glia cell layer.
Journal ArticleDOI
Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
Hengli Tang,Christy Hammack,Sarah C. Ogden,Zhexing Wen,Xuyu Qian,Yujing Li,Bing Yao,Jaehoon Shin,Feiran Zhang,Emily M. Lee,Kimberly M. Christian,Ruth Didier,Peng Jin,Hongjun Song,Guo Li Ming +14 more
TL;DR: It is shown that a strain of the ZIKV, MR766, serially passaged in monkey and mosquito cells efficiently infects human neural progenitor cells (hNPCs) derived from induced pluripotent stem cells, identified as a direct ZikV target, and reveals transcriptional dysregulation, notably of cell-cycle-related pathways.
Journal ArticleDOI
Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome
Victoria Brown,Victoria Brown,Peng Jin,Peng Jin,Stephanie Ceman,Stephanie Ceman,Jennifer C. Darnell,William T. O'Donnell,William T. O'Donnell,Scott A. Tenenbaum,Xiaokui Jin,Yue Feng,Keith D. Wilkinson,Jack D. Keene,Robert B. Darnell,Stephen T. Warren,Stephen T. Warren +16 more
TL;DR: It is concluded that translational dysregulation of mRNAs normally associated with FMRP may be the proximal cause of fragile X syndrome, and candidate genes relevant to this phenotype are identified.
Journal ArticleDOI
Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome
Miao Yu,Gary C. Hon,Keith E. Szulwach,Chun-Xiao Song,Liang Zhang,Audrey Kim,Xuekun Li,Qing Dai,Yin Shen,Beomseok Park,Jung Hyun Min,Peng Jin,Bing Ren,Chuan He +13 more
TL;DR: Application of Tet-assisted bisulfite sequencing to embryonic stem cells not only confirms widespread distribution of 5hmC in the mammalian genome but also reveals sequence bias and strand asymmetry at5hmC sites.
Journal ArticleDOI
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
Chun-Xiao Song,Keith E. Szulwach,Ye Fu,Qing Dai,Chengqi Yi,Xuekun Li,Yujing Li,Chih Hsin Chen,Wen Zhang,Xing Jian,Jing Wang,Li Zhang,Timothy J. Looney,Baichen Zhang,Lucy A. Godley,Leslie M. Hicks,Bruce T. Lahn,Peng Jin,Chuan He +18 more
TL;DR: This method uses the T4 bacteriophage β-glucosyltransferase to transfer an engineered glucose moiety containing an azide group onto the hydroxyl group of 5-hmC, a recently identified epigenetic modification present in substantial amounts in certain mammalian cell types.