Z
Zhaohui Ao
Researcher at GlaxoSmithKline
Publications - 19
Citations - 1585
Zhaohui Ao is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Receptor & Urotensin-II. The author has an hindex of 14, co-authored 19 publications receiving 1538 citations.
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Journal ArticleDOI
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
Robert S. Ames,Henry M. Sarau,Johathan K. Chambers,Robert N. Willette,Nambi Aiyar,Anne M. Romanic,Calvert Louden,James J. Foley,Charles F. Sauermelch,Robert W. Coatney,Zhaohui Ao,Jyoti Disa,Stephen Dudley Holmes,Jeffrey M. Stadel,John D. Martin,Wu-Schyong Liu,George I. Glover,Shelagh Wilson,Dean E. McNulty,Catherine E. Ellis,Nabil Elshourbagy,Usman Shabon,John J. Trill,Douglas W. P. Hay,Eliot H. Ohlstein,Derk J. Bergsma,Stephen A. Douglas +26 more
TL;DR: The identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor, the most potent mammalian vasoconstrictor identified so far.
Journal ArticleDOI
Molecular and pharmacological characterization of genes encoding urotensin-II peptides and their cognate G-protein-coupled receptors from the mouse and monkey
Nabil Elshourbagy,Stephen A. Douglas,Usman Shabon,Stephen M. Harrison,Graham Duddy,Jan L. Sechler,Zhaohui Ao,Beverly E. Maleeff,Diane Naselsky,Jyoti Disa,Nambi Aiyar +10 more
TL;DR: In this article, the U-II and its receptor (UT) represent novel therapeutic targets for management of a variety of cardiovascular diseases, and it will be necessary to develop experimental animal models for the manipulation of Urotensin-II/UT receptor system.
Journal ArticleDOI
Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells.
Nambi Aiyar,Jyoti Disa,Zhaohui Ao,Haisong Ju,Sandhya S. Nerurkar,Robert N. Willette,Colin H. Macphee,Douglas G. Johns,Stephen A. Douglas +8 more
TL;DR: Stimulation of arachidonic acid, inflammatory cytokines and growth factor release, implies that LPC might play a multifactorial role in the progression of atherosclerosis, by affecting inflammatory processes.
Journal ArticleDOI
Effects of p38 MAPK Inhibitor on angiotensin II-dependent hypertension, organ damage, and superoxide anion production.
Weike Bao,David J. Behm,Sandhya S. Nerurkar,Zhaohui Ao,Ross G. Bentley,Rosanna C. Mirabile,Douglas G. Johns,Tina N Woods,Christopher P. Doe,Robert W. Coatney,Jason F Ohlstein,Stephen A. Douglas,Robert N. Willette,Tian-Li Yue +13 more
TL;DR: The results suggest that Ang II induced hypertension, organ damage, and ROS production are possibly mediated by p38 MAPK and inhibition of p38MAPK may offer a therapeutic approach for cardiovascular disease.
Journal Article
Endothelin B receptor modulates inflammatory pain and cutaneous inflammation.
Don E. Griswold,Stephen A. Douglas,Lenox D. Martin,T. Gregg Davis,Laura Davis,Zhaohui Ao,Mark A. Luttmann,Mark Pullen,Ponnal Nambi,Douglas W. P. Hay,Eliot H. Ohlstein +10 more
TL;DR: The results implicate the ET(B) receptor in mediation of inflammatory pain and cutaneous inflammatory responses in mice.