Derk J. Bergsma

TL;DR: Two novel neuropeptides are identified, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors in the hypothalamus of rats.

TL;DR: High potency agonism was evident from peptides derived from the gene KiSS-1, the expression of which prevents metastasis in melanoma cells, and the nature of the putative cognate ligand for AXOR12 are discussed.

TL;DR: The identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor, the most potent mammalian vasoconstrictor identified so far.

TL;DR: It is shown that UDP-glucose, and some closely related molecules, potently activate the orphan G protein-coupled receptor KIAA0001 heterologously expressed in yeast or mammalian cells, suggesting that some sugar-nucleotides may serve important physiological roles as extracellular signaling molecules in addition to their familiar role in intermediary metabolism.

TL;DR: The discovery of this CysLTR receptor, which has characteristics of the purported CysLT(1) receptor subtype, should assist in the elucidation of the pathophysiological roles of the Cys LTs and in the identification of additional receptor subtypes.