U
Usman Shabon
Researcher at GlaxoSmithKline
Publications - 50
Citations - 3644
Usman Shabon is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Polynucleotide & G protein-coupled receptor. The author has an hindex of 13, co-authored 49 publications receiving 3499 citations.
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Journal ArticleDOI
The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids
Celia P. Briscoe,Mohammad Tadayyon,E. John L. Andrews,William G. Benson,Jon K. Chambers,Michelle M. Eilert,Catherine E. Ellis,Nabil Elshourbagy,Aaron S. Goetz,Dana T. Minnick,Paul R. Murdock,Howard Ray Sauls,Usman Shabon,Lisa D. Spinage,Jay C. Strum,Philip G. Szekeres,Kong B. Tan,James M. Way,Diane M. Ignar,Shelagh Wilson,Alison I. Muir +20 more
TL;DR: expression analysis by quantitative reverse transcription-PCR showed that GPR40 was specifically expressed in brain and Pancreas, with expression in rodent pancreas being localized to insulin-producing β-cells.
Journal ArticleDOI
AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1
Alison I. Muir,Larissa Chamberlain,Nabil Elshourbagy,David Michalovich,Darren J. Moore,Amy Calamari,Philip G. Szekeres,Henry M. Sarau,Jon K. Chambers,Paul R. Murdock,Klaudia Steplewski,Usman Shabon,Jane E. Miller,Susan E. Middleton,John G. Darker,Christopher Larminie,Shelagh Wilson,Derk J. Bergsma,Piers C. Emson,Richard L.M. Faull,Karen L. Philpott,David C. Harrison +21 more
TL;DR: High potency agonism was evident from peptides derived from the gene KiSS-1, the expression of which prevents metastasis in melanoma cells, and the nature of the putative cognate ligand for AXOR12 are discussed.
Journal ArticleDOI
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
Robert S. Ames,Henry M. Sarau,Johathan K. Chambers,Robert N. Willette,Nambi Aiyar,Anne M. Romanic,Calvert Louden,James J. Foley,Charles F. Sauermelch,Robert W. Coatney,Zhaohui Ao,Jyoti Disa,Stephen Dudley Holmes,Jeffrey M. Stadel,John D. Martin,Wu-Schyong Liu,George I. Glover,Shelagh Wilson,Dean E. McNulty,Catherine E. Ellis,Nabil Elshourbagy,Usman Shabon,John J. Trill,Douglas W. P. Hay,Eliot H. Ohlstein,Derk J. Bergsma,Stephen A. Douglas +26 more
TL;DR: The identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor, the most potent mammalian vasoconstrictor identified so far.
Journal ArticleDOI
Receptor for the Pain Modulatory Neuropeptides FF and AF Is an Orphan G Protein-coupled Receptor
Nabil Elshourbagy,Robert S. Ames,Laura R. Fitzgerald,James J. Foley,Jon K. Chambers,Philip G. Szekeres,Nicholas A. Evans,Dulcie B. Schmidt,Peter T. Buckley,George M. Dytko,Paul R. Murdock,Graeme Milligan,D. Alex Groarke,Kong B. Tan,Usman Shabon,Parvathi Nuthulaganti,Da Yuan Wang,Shelagh Wilson,Derk J. Bergsma,Henry M. Sarau +19 more
TL;DR: expression of HLWAR77 was demonstrated in brain regions associated with opiate activity, consistent with the pain-modulating activity of these peptides, whereas the expression in adipose tissue suggests other physiological and pathophysiological activities for FMRF-amide neuropeptides.
Journal ArticleDOI
The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects
Douglas G. Johns,Behm Dj,Walker Dj,Zhaohui Ao,Ellen M. Shapland,Daniels Da,Riddick M,Simon J. Dowell,Staton Pc,Green P,Usman Shabon,Bao W,Nambi V. Aiyar,Yue Tl,Andrew J. Brown,Alastair Morrison,Stephen A. Douglas +16 more
TL;DR: The purpose of the present study was to test the hypothesis that human recombinant GPR55 is activated by atypical cannabinoids and mediates vasodilator responses to these agents.