Z
Zhaohui Feng
Researcher at Rutgers University
Publications - 99
Citations - 10576
Zhaohui Feng is an academic researcher from Rutgers University. The author has contributed to research in topics: Carcinogenesis & Gene. The author has an hindex of 48, co-authored 93 publications receiving 9005 citations. Previous affiliations of Zhaohui Feng include New York University & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
The coordinate regulation of the p53 and mTOR pathways in cells.
TL;DR: The results presented here demonstrate that activation of p53 inhibits mTOR activity and regulates its downstream targets, including autophagy, a tumor suppression process, and that p53 and mTOR signaling machineries can cross-talk and coordinately regulate cell growth, proliferation, and death.
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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
TL;DR: Results demonstrated that as a unique p53 target gene, GLS2 is a mediator of p53’s role in energy metabolism and antioxidant defense, which can contribute to its role in tumor suppression.
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The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways
Zhaohui Feng,Wenwei Hu,Elisa de Stanchina,Angelika K. Teresky,Shengkan Jin,Scott W. Lowe,Arnold J. Levine +6 more
TL;DR: This study explores four p53-regulated gene products, the beta1 and beta2 subunits of the AMPK, which are shown for the first time to be regulated by the p53 protein, TSC2, PTEN, and IGF-BP3, each of which negatively regulates the IGF-1-AKT-mTOR pathways after stress.
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p53 regulates maternal reproduction through LIF
TL;DR: A function for p53 in maternal reproduction through the regulation of LIF is demonstrated, in a gender-specific manner, and evidence is accumulating that p53 may have a similar function in humans.
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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
TL;DR: The results suggest that as a novel component in the p53 pathway, Parkin contributes to the functions of p53 in regulating energy metabolism, especially the Warburg effect, and antioxidant defense, and thus the function of p 53 in tumor suppression.