R
Rui Wu
Researcher at Rutgers University
Publications - 10
Citations - 2154
Rui Wu is an academic researcher from Rutgers University. The author has contributed to research in topics: Warburg effect & Regulation of gene expression. The author has an hindex of 9, co-authored 10 publications receiving 1836 citations. Previous affiliations of Rui Wu include University of Medicine and Dentistry of New Jersey & Zhejiang University.
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Journal ArticleDOI
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
TL;DR: Results demonstrated that as a unique p53 target gene, GLS2 is a mediator of p53’s role in energy metabolism and antioxidant defense, which can contribute to its role in tumor suppression.
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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
TL;DR: The results suggest that as a novel component in the p53 pathway, Parkin contributes to the functions of p53 in regulating energy metabolism, especially the Warburg effect, and antioxidant defense, and thus the function of p 53 in tumor suppression.
Journal ArticleDOI
Tumour-associated mutant p53 drives the Warburg effect.
Cen Zhang,Juan Liu,Yingjian Liang,Rui Wu,Yuhan Zhao,Xuehui Hong,Meihua Lin,Haiyang Yu,Lianxin Liu,Arnold J. Levine,Wenwei Hu,Zhaohui Feng +11 more
TL;DR: It is shown that tumor-associatedmutp53 stimulates the Warburg effect in cultured cells and mutp53 knock-in mice as a new mutp 53 gain-of-function (GOF) and a mechanism for controlling the Warberg effect is revealed.
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Negative regulation of tumor suppressor p53 by microRNA miR-504.
Wenwei Hu,Chang S. Chan,Rui Wu,Cen Zhang,Yvonne Sun,Jun S. Song,Laura H. Tang,Arnold J. Levine,Arnold J. Levine,Zhaohui Feng +9 more
TL;DR: Overexpression of miR-504 decreases p53 protein levels and functions in cells, including p53 transcriptional activity, p53-mediated apoptosis, and cell-cycle arrest in response to stress, which promotes tumorigenecity of cells in vivo.
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Tumor suppressor p53 meets microRNAs
TL;DR: These findings have demonstrated that miRNAs are important components in the p53 network, and also added another layer of complexity to the p 53 network.