Z
Zhen Tao
Researcher at Tianjin Medical University Cancer Institute and Hospital
Publications - 23
Citations - 839
Zhen Tao is an academic researcher from Tianjin Medical University Cancer Institute and Hospital. The author has contributed to research in topics: Tumor microenvironment & Medicine. The author has an hindex of 11, co-authored 17 publications receiving 596 citations. Previous affiliations of Zhen Tao include Thomas Jefferson University & Tianjin Medical University.
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Journal ArticleDOI
miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
Shaohua Xu,Zhen Tao,Bo Hai,Huagen Liang,Ying Shi,Tao Wang,Wen Song,Yong Chen,Jun OuYang,Jinhong Chen,Fanfei Kong,Yishan Dong,Shi Wen Jiang,Weiyong Li,Ping Wang,Zhiyong Yuan,Xiaoping Wan,Chenguang Wang,Wencheng Li,Xiaoping Zhang,Ke Chen +20 more
TL;DR: It is demonstrated that miR-424(322) regulates the PD-L1/PD-1 and CD80/CTLA-4 pathways in chemoresistant ovarian cancer, and data suggest a biological and functional interaction between PD- L1 and chemoresistance through the microRNA regulatory cascade.
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Coadministration of Trametinib and Palbociclib Radiosensitizes KRAS-Mutant Non-Small Cell Lung Cancers In Vitro and In Vivo
Zhen Tao,Zhen Tao,Justin M Le Blanc,Chenguang Wang,Tingting Zhan,Hongqing Zhuang,Ping Wang,Zhiyong Yuan,Bo Lu +8 more
TL;DR: The findings suggest that MEK inhibitor in combination with CDK4/6 inhibitor has significant anti-KRAS–mutant NSCLC activity and radiosensitizing effect in preclinical models, potentially providing a novel therapeutic strategy for patients with advanced KRAS-mutants NSCLCs.
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Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes.
Junyi Hu,Zhaohui Chen,Lin Bao,Lijie Zhou,Yaxin Hou,Lilong Liu,Ming Xiong,Yuhan Zhang,Bin Wang,Zhen Tao,Ke Chen +10 more
TL;DR: This study verified that T cell exhaustion was the key factor responsible for the immunosuppressive property of ccRCC tissues, which was significantly related to poor prognosis, and found that abnormal metabolic patterns occurred not only in cancer cells, but also in tumor-infiltrating stromal cells.
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Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells
Xuejun Sun,Chongwen Xu,Shou Ching Tang,Jiansheng Wang,Huangzhen Wang,Peili Wang,Ning Du,Sida Qin,Gang Li,Shaohua Xu,Zhen Tao,Dapeng Liu,Hong Ren +12 more
TL;DR: These findings identified a biochemical and functional link between let-7c with ERα/Wnt signaling in breast cancer stem cells and found that higher expression levels of let- 7b and let-8c were correlated with better clinical prognosis of patients with estrogen receptor (ER)α-positive breast tumor.
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MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1
TL;DR: The results demonstrated that overexpression of miR-497 sensitizes the resistant ovarian tumor to cisplatin treatment, and it is suggested that mi R-497 might be used as a therapeutic supplement to increase ovarian cancer treatment response to cis Platin.