K
Ke Chen
Researcher at Huazhong University of Science and Technology
Publications - 116
Citations - 3655
Ke Chen is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Clear cell renal cell carcinoma & Cancer. The author has an hindex of 29, co-authored 109 publications receiving 2460 citations. Previous affiliations of Ke Chen include Thomas Jefferson University.
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Journal ArticleDOI
miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
Shaohua Xu,Zhen Tao,Bo Hai,Huagen Liang,Ying Shi,Tao Wang,Wen Song,Yong Chen,Jun OuYang,Jinhong Chen,Fanfei Kong,Yishan Dong,Shi Wen Jiang,Weiyong Li,Ping Wang,Zhiyong Yuan,Xiaoping Wan,Chenguang Wang,Wencheng Li,Xiaoping Zhang,Ke Chen +20 more
TL;DR: It is demonstrated that miR-424(322) regulates the PD-L1/PD-1 and CD80/CTLA-4 pathways in chemoresistant ovarian cancer, and data suggest a biological and functional interaction between PD- L1 and chemoresistance through the microRNA regulatory cascade.
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Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma
TL;DR: It is found that tumor cells down regulated MHC-II molecules, suggesting that the downregulated immunogenicity of cancer cells may contribute to the formation of an immunosuppressive microenvironment.
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LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma
Haibing Xiao,Kun Tang,Peijun Liu,Ke Chen,Junhui Hu,Jin Zeng,Wei Xiao,Gan Yu,Weiming Yao,Hui Zhou,Heng Li,Yingtian Pan,Anping Li,Zhangqun Ye,Ji Wang,Hua Xu,Qihong Huang +16 more
TL;DR: It is found that MALAT1 exist a higher fold change (Tumor/Normal) in clear cell kidney carcinoma (KIRC) from The Cancer Genome Atlas (TCGA) Data Portal and a negative correlation with miR-200s family.
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Pseudogene PTENP1 Functions as a Competing Endogenous RNA to Suppress Clear-Cell Renal Cell Carcinoma Progression
Gan Yu,Weimin Yao,Kiranmai Gumireddy,Anping Li,Ji Wang,Wei Xiao,Ke Chen,Haibing Xiao,Heng Li,Kun Tang,Zhangqun Ye,Qihong Huang,Hua Xu +12 more
TL;DR: It is suggested that PTENP1 functions as a competing endogenous RNA (ceRNA) in ccRCC to suppress cancer progression and recapitulating the phenotypes induced by PTEN expression.
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EYA1 Phosphatase Function Is Essential To Drive Breast Cancer Cell Proliferation Through Cyclin D1
Kongming Wu,Zhaoming Li,Shaoxin Cai,Lifeng Tian,Ke Chen,Jing Wang,Junbo Hu,Ye Sun,Xue Li,Adam Ertel,Richard G. Pestell +10 more
TL;DR: The Drosophila Eyes Absent Homologue 1 (EYA1) is a component of the retinal determination gene network and serves as an H2AX phosphatase.