Zhenmei Li

TL;DR: FabB[H333N] was significantly more resistant to both antibiotics than FabB and had an affinity for TLM an order of magnitude less than the wild-type enzyme, illustrating that the two-histidine active site architecture is critical to protein-antibiotic interaction.

TL;DR: Structures of a target enzyme in the bacteria that cause anthrax and bubonic plague may lead to effective drugs, and structural, computational, and mutagenesis studies on the catalytic and resistance mechanisms of DHPS are reported.

TL;DR: It is suggested that the binding of acyl-CoA disrupts a buried network of charged and polar residues in the C-terminal domain, and the resulting conformational change is transmitted to the N-terminAL domain via a domain-spanning α-helix.

TL;DR: Using a prototypical endonuclease inhibitor (L-742,001), mutagenesis was used to select for replication competent resistant mutants and studied the structural and functional basis for the observed resistance, confirming that the end onuclease domain is an excellent drug target for treating influenza.

TL;DR: It is shown that multiple histone dem methylases influence the viability and poor prognosis of neuroblastoma cells, where MYC is often overexpressed, and the approved small-molecule antifungal agent ciclopirox is identified as a novel pan-histone demethylase inhibitor.