R
Richard E. Lee
Researcher at St. Jude Children's Research Hospital
Publications - 193
Citations - 7847
Richard E. Lee is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Mycobacterium tuberculosis & Dihydropteroate synthase. The author has an hindex of 45, co-authored 176 publications receiving 6648 citations. Previous affiliations of Richard E. Lee include University of Tennessee Health Science Center.
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Journal ArticleDOI
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections
TL;DR: Despite some drawbacks, membrane-active agents form an important new means of eradicating recalcitrant, non-growing bacteria.
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Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
Anna E. Grzegorzewicz,Ha Pham,Vijay A. K.B. Gundi,Michael S. Scherman,Elton J. North,Tamara Hess,Victoria Jones,Veronica Gruppo,Sarah E. M. Born,Jana Korduláková,Sivagami Sundaram Chavadi,Christophe Morisseau,Anne J. Lenaerts,Richard E. Lee,Michael R. McNeil,Mary Jackson +15 more
TL;DR: Experiments revealed that the prototype inhibitor targets the inner membrane transporter, MmpL3, and support the involvement of this transporter in the translocation of trehalose monomycolate across the plasma membrane.
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Validation of molecular docking programs for virtual screening against dihydropteroate synthase.
Kirk E. Hevener,Wei Zhao,Wei Zhao,David M. Ball,David M. Ball,Kerim Babaoglu,Kerim Babaoglu,Jianjun Qi,Jianjun Qi,Stephen W. White,Stephen W. White,Richard E. Lee,Richard E. Lee +12 more
TL;DR: Of the docking and scoring functions evaluated, Surflex with Surflex-Score and Glide with GlideScore were the best overall performers for use in virtual screening against the DHPS target, with neither combination showing statistically significant superiority over the other in enrichment studies or pose selection.
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Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans
Teresa T. Liu,Robin E. B. Lee,Katherine S. Barker,Richard E. Lee,Lai Wei,Ramin Homayouni,P. David Rogers +6 more
TL;DR: Changes in the gene expression profile of Candida albicans following exposure to representatives of the four currently available classes of antifungal agents used in the treatment of systemic fungal infections are examined.
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New agents for the treatment of drug-resistant Mycobacterium tuberculosis
TL;DR: The challenges to developing drugs to treat tuberculosis are discussed and how the field has adapted to these difficulties, with an emphasis on drug discovery approaches that might produce more effective agents and treatment regimens.