Z
Zhenmei Liao
Researcher at Sunesis Pharmaceuticals
Publications - 3
Citations - 3375
Zhenmei Liao is an academic researcher from Sunesis Pharmaceuticals. The author has contributed to research in topics: BACE1-AS & Presenilin. The author has an hindex of 3, co-authored 3 publications receiving 3291 citations.
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Journal ArticleDOI
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
Dale Schenk,Robin Barbour,Whitney Dunn,Grace Gordon,Henry Grajeda,Teresa Guido,Kang Hu,Jiping Huang,Kelly Johnson-Wood,Karen Khan,Dora Kholodenko,Michael K. Lee,Zhenmei Liao,Ivan Lieberburg,Ruth Motter,Linda Mutter,Ferdie Soriano,George Shopp,Vasquez Nicki J,Christopher Vandevert,Shannan Walker,Mark Wogulis,Ted Yednock,Dora Games,Peter Seubert +24 more
TL;DR: It is reported that immunization of the young animals essentially prevented the development of β-amyloid-plaque formation, neuritic dystrophy and astrogliosis, and treatment of the older animals markedly reduced the extent and progression of these AD-like neuropathologies.
Journal ArticleDOI
Orally available and efficacious α4β1/α4β7 integrin inhibitors.
Ying-Zi Xu,Jenifer L. Smith,Christopher M. Semko,Kassandra Inez Rossiter,Juri Y Fukuda,Michael S. Dappen,David A. Quincy,Andrei W. Konradi,Wenxian Mao,Brent Welch,Mark Dreyer,Bhushan Samant,Hongbin Zhang,Judevin Lugar,Zhenmei Liao,Carrol Henschel,Eric Petersen,Christopher Vandevert,Mark Shoemaker,Nancy G. Wehner,Linda Mutter,George Shopp,Michael Krimm,Linda Chen,Brian Wipke,Lilibeth Dofiles,Ian Gallager,John-Michael Sauer,Elizabeth Messersmith,Michael A. Pleiss,Frederique Bard,Ted Yednock +31 more
TL;DR: A series of potent α4β1/α4β7 integrin inhibitors is reported, including an inhibitor 12d with remarkable oral exposure and efficacy in rat models of rheumatoid arthritis and Crohn's disease.
Journal ArticleDOI
Arylsulfonamide pyrimidines as VLA-4 antagonists.
Ying-Zi Xu,Andrei W. Konradi,Frederique Bard,Michael S. Dappen,Lilibeth Dofiles,Mark Dreyer,Ian Gallager,Caroline Garrido,Mike Krimm,Zhenmei Liao,Elizabeth Messersmith,Linda Mutter,Michael A. Pleiss,Bhushan Samant,Semko Christopher M,Jennifer S. Smith,Frank Stappenbeck,Brian P. Stupi,Chris Vandervert,Brent Welch,Brian Wipke,Ted Yednock +21 more
TL;DR: A series of (S)-2-(2-(diethylamino)-5-(N-alkyl-N-sulfonamido)pyrimidin-4-ylamino-3-(4-(carbamoyloxy)phenyl)propanoic acid is discovered as orally available VLA-4 antagonists and showed efficacy in multiple in vivo animal models.