K
Kang Hu
Researcher at Élan
Publications - 15
Citations - 10734
Kang Hu is an academic researcher from Élan. The author has contributed to research in topics: Amyloid precursor protein & P3 peptide. The author has an hindex of 11, co-authored 13 publications receiving 10372 citations. Previous affiliations of Kang Hu include Pharmacia & Sunesis Pharmaceuticals.
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Journal ArticleDOI
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
Dale Schenk,Robin Barbour,Whitney Dunn,Grace Gordon,Henry Grajeda,Teresa Guido,Kang Hu,Jiping Huang,Kelly Johnson-Wood,Karen Khan,Dora Kholodenko,Michael K. Lee,Zhenmei Liao,Ivan Lieberburg,Ruth Motter,Linda Mutter,Ferdie Soriano,George Shopp,Vasquez Nicki J,Christopher Vandevert,Shannan Walker,Mark Wogulis,Ted Yednock,Dora Games,Peter Seubert +24 more
TL;DR: It is reported that immunization of the young animals essentially prevented the development of β-amyloid-plaque formation, neuritic dystrophy and astrogliosis, and treatment of the older animals markedly reduced the extent and progression of these AD-like neuropathologies.
Journal ArticleDOI
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease.
Frederique Bard,Catherine Cannon,Robin Barbour,Rae Lyn Burke,Dora Games,Henry Grajeda,Teresa Guido,Kang Hu,Jiping Huang,Kelly Johnson-Wood,Karen Khan,Dora Kholodenko,Michael K. Lee,Ivan Lieberburg,Ruth Motter,Minh Nguyen,Ferdie Soriano,Vasquez Nicki J,Kim Weiss,Brent Welch,Peter Seubert,Dale Schenk,Ted Yednock +22 more
TL;DR: Results indicate that antibodies can cross the blood–brain barrier to act directly in the central nervous system and should be considered as a therapeutic approach for the treatment of Alzheimer disease and other neurological disorders.
Journal ArticleDOI
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.
Lennart Mucke,Eliezer Masliah,Gui-Qiu Yu,Margaret Mallory,Edward Rockenstein,Gwen Tatsuno,Kang Hu,Dora Kholodenko,Kelly Johnson-Wood,Lisa McConlogue +9 more
TL;DR: It is concluded that Aβ is synaptotoxic even in the absence of plaques and that high levels of Aβ1–42 are insufficient to induce plaque formation in mice expressing wild-type hAPP, supporting the emerging view that plaque-independent Aβ toxicity plays an important role in the development of synaptic deficits in AD and related conditions.
Journal ArticleDOI
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.
Albert Y. Hsia,Eliezer Masliah,Lisa McConlogue,Gui Qiu Yu,Gwen Tatsuno,Kang Hu,Dora Kholodenko,Robert C. Malenka,Roger A. Nicoll,Lennart Mucke +9 more
TL;DR: It is shown that overexpression of FAD(717V-->F)-mutant human APP in neurons of transgenic mice decreases the density of presynaptic terminals and neurons well before these mice develop amyloid plaques, suggesting a neurotoxic effect of Abeta that is independent of plaque formation.
Journal ArticleDOI
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
Steven L. Roberds,John P. Anderson,Guriqbal Basi,Michael Jerome Bienkowski,Daniel G. Branstetter,Karen S. Chen,Stephen B. Freedman,Normand Frigon,Dora Kate Games,Kang Hu,Kelly Johnson-Wood,Karl Kappenman,Thomas T. Kawabe,Ismail Kola,Ralf Kuehn,Mike Lee,Weiqun Liu,Ruth Motter,Nanette F. Nichols,Michael Power,David W. Robertson,Dale Schenk,Michael Schoor,George Shopp,Mary E. Shuck,Sukanto Sinha,Kjell A. Svensson,Gwen Tatsuno,Hartmut Tintrup,John A. Wijsman,Sarah Wright,Lisa McConlogue +31 more
TL;DR: The findings that BACE is the primary beta- secretase activity in brain and that loss of beta-secretase activity produces no profound phenotypic defects with a concomitant reduction in beta-amyloid peptide clearly indicate that Bace is an excellent therapeutic target for treatment of AD.