Zhentai Zhu

TL;DR: A surface plasmon resonance (SPR) biosensor using an anti-OTA aptamer immobilized sensor chip was developed to measure ochratoxin A quantificationally through a straightforward direct binding assay, showing good analytical performances with limits of detection much lower than the maximum residue limit, as well as good reproducibility and stability.

TL;DR: The developed SPR assay is a simple, fast and sensitive approach for the detection of residual AFBs in agricultural products and foodstuffs like vinegar, and shows high specificity towards AFB1 and AFB2, but hardly bound to other toxins with similar structures.

TL;DR: ZXR-2 showed broad-spectrum activity against a variety of Gram-positive and Gram-negative oral bacteria, particularly the caries-related taxa Streptococcus mutans, and represents a potential therapeutic for the prevention and treatment of dental caries.

TL;DR: A novel anticancer peptide ZXR-1 derived from a known anticancers peptide mauriporin was developed, and a mutant ZxR-2 with only one residue difference at the 14th position (Lys→Leu) was also engineered, displaying distinct anticancer modes of action.

TL;DR: A series of analogs of a recently discovered CPP ZXR-1 are designed by varying the charge distributions both on the helical wheel projection and along the sequence to provide a further understanding about the effect of charge distribution on the functions of membrane-active peptides, and will be helpful for the design of functional peptides.