Z
Zhenxin Li
Researcher at Fudan University
Publications - 16
Citations - 1129
Zhenxin Li is an academic researcher from Fudan University. The author has contributed to research in topics: Neuromyelitis optica & Experimental autoimmune encephalomyelitis. The author has an hindex of 9, co-authored 14 publications receiving 1053 citations. Previous affiliations of Zhenxin Li include Fudan University Shanghai Medical College.
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Journal ArticleDOI
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis.
Changsheng Du,Chang Liu,Jiuhong Kang,Jiuhong Kang,Gui-Xian Zhao,Zhi-Qiang Ye,Shichao Huang,Zhenxin Li,Zhiying Wu,Gang Pei,Gang Pei +10 more
TL;DR: A TH-17 cell–associated microRNA, miR-326, is identified whose expression was highly correlated with disease severity in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis, and its overexpression led to more TH- 17 cells and severe EAE.
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Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1.
Yufeng Shi,Yan Feng,Jiuhong Kang,Chang Liu,Zhenxin Li,Dangsheng Li,Wei Cao,Ju Qiu,Zhengliang Guo,Enguang Bi,Lei Zang,Chuanzhen Lu,Jingwu Z Zhang,Jingwu Z Zhang,Gang Pei +14 more
TL;DR: It is demonstrated that the multifunctional adaptor protein β-arrestin 1 positively regulated naive and activated CD4+ T cell survival and is a factor in susceptibility to autoimmunity.
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Blocking A2B Adenosine Receptor Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis via Inhibition of IL-6 Production and Th17 Differentiation
Wei Wei,Changsheng Du,Jie Lv,Jie Lv,Gui-Xian Zhao,Zhenxin Li,Zhiying Wu,György Haskó,Xin Xie,Xin Xie +9 more
TL;DR: It is discovered that A2BAR was upregulated both in the peripheral blood leukocytes of MS patients and the peripheral lymphoid tissues of experimental autoimmune encephalomyelitis mice and suggested that this receptor might be a new therapeutic target for the development of anti-MS drugs.
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Impaired regulatory function and enhanced intrathecal activation of B cells in neuromyelitis optica: distinct from multiple sclerosis
TL;DR: The results further define the distinct immunological nature of NMO and RRMS from the B cell perspective and suggest an enhanced intrathecal B cell recruitment and activation.
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The Antiepileptic Drug Valproic Acid Restores T Cell Homeostasis and Ameliorates Pathogenesis of Experimental Autoimmune Encephalomyelitis
Jie Lv,Jie Lv,Changsheng Du,Wei Wei,Wei Wei,Zhiying Wu,Gui-Xian Zhao,Zhenxin Li,Xin Xie,Xin Xie +9 more
TL;DR: VPA was found to reduce spinal cord inflammation, demyelination, and disease scores in experimental autoimmune encephalomyelitis, a mouse model of MS and indicated that VPA induces apoptosis in activated T cells and maintains the immune homeostasis.