J
Ju Qiu
Researcher at Chinese Academy of Sciences
Publications - 41
Citations - 3044
Ju Qiu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Innate lymphoid cell & Medicine. The author has an hindex of 16, co-authored 24 publications receiving 2378 citations. Previous affiliations of Ju Qiu include Albert Einstein College of Medicine & Northwestern University.
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Journal ArticleDOI
The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells.
Ju Qiu,Jennifer J. Heller,Xiaohuan Guo,Zong ming E. Chen,Kamonwan Fish,Yang Xin Fu,Liang Zhou +6 more
TL;DR: It is shown that the aryl hydrocarbon receptor (Ahr) plays an essential role in RORγt(+) ILC maintenance and function, and a previously unrecognized physiological role for Ahr in promoting innate gut immunity by regulating R ORγt (+) I LCs is uncovered.
Journal ArticleDOI
Commensal bacteria protect against food allergen sensitization
Andrew T. Stefka,Taylor Feehley,Prabhanshu Tripathi,Ju Qiu,Kathleen McCoy,Sarkis K. Mazmanian,Melissa Y Tjota,Goo-Young Seo,Severine Cao,Betty Theriault,Dionysios A. Antonopoulos,Liang Zhou,Eugene B. Chang,Yang Xin Fu,Cathryn R. Nagler +14 more
TL;DR: It is shown here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota, and this data support the development of novel adjunctive probiotic therapies to potentiate the induction of tolerance to dietary allergens.
Journal ArticleDOI
Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora
Ju Qiu,Xiaohuan Guo,Zong ming E. Chen,Lei He,Gregory F. Sonnenberg,David Artis,Yang Xin Fu,Liang Zhou +7 more
TL;DR: An intricate balance between group 3 innate lymphoid cells and Th17 cells regulated by Ahr and commensal flora is revealed, raising the possibility that group 3 ILCs could negatively regulate Th 17 cells.
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Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection
Xiaohuan Guo,Ju Qiu,Tony Tu,Xuanming Yang,Liufu Deng,Robert A. Anders,Liang Zhou,Yang Xin Fu +7 more
TL;DR: Cancer therapies that utilize STAT3 inhibitors increase the risk for pathogen-mediated diarrhea through direct suppression of IL-22 from gut ILCs through directly binding to the Il22 locus.
Journal ArticleDOI
Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage
Xinyang Song,Dai Dai,Xiao He,Shu Zhu,Yikun Yao,Gao Hanchao,Jingjing Wang,Fangfang Qu,Ju Qiu,Honglin Wang,Xiaoxia Li,Nan Shen,Youcun Qian +12 more
TL;DR: Growth factor FGF2 synergized with interleukin-17 (IL-17) to induce genes for repairing of damaged epithelium through Act1-mediated direct signaling cross-talk in a DSS-induced colitis model.