Z
Zhenzhen Hu
Researcher at Nanjing Medical University
Publications - 12
Citations - 547
Zhenzhen Hu is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Cell migration & Signal transduction. The author has an hindex of 9, co-authored 11 publications receiving 458 citations.
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Journal ArticleDOI
Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration.
TL;DR: It is demonstrated for the first time that Wnt5a promotes breast cancer cell migration via Dvl2/Daam1/RhoA through Ectopic expression of dominant negative RhoA or C3 exoenzyme transferase, a Rho inhibitor.
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Lysophosphatidic Acid Induces MDA-MB-231 Breast Cancer Cells Migration through Activation of PI3K/PAK1/ERK Signaling
TL;DR: The data suggest that ROS generation plays an essential role in the activation of LPA-stimulated PI3K/PAK1/ERK signaling and breast cancer cell migration, and may provide a basis for designing future therapeutic strategy for blocking breast cancer metastasis.
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PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1α expression in MCF-7 breast cancer cells.
TL;DR: It is demonstrated that hypoxia-induced HIF-1α expression involves a cascade of signaling events including ROS generation, activation of PI3K and ERK signaling, and subsequent activation of Rac1.
Journal ArticleDOI
PI3K/Akt-dependent phosphorylation of GSK3β and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration.
Jiaojing Liu,Yujie Zhang,Rui Xu,Jun Du,Zhenzhen Hu,Ling Yang,Yongchang Chen,Yichao Zhu,Luo Gu +8 more
TL;DR: It is demonstrated for the first time that Wnt5a promoted gastric cancer cell migration via the PI3K/Akt/GSK3β/RhoA signaling pathway.
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Activation of Rac1-PI3K/Akt is required for epidermal growth factor-induced PAK1 activation and cell migration in MDA-MB-231 breast cancer cells
TL;DR: EGF treatment could activate Ras-related C3 botulinum toxin substrate 1 (Rac1), PI3K/Akt and p21-actived kinase (PAK1) along with cell migration, and it was demonstrated that EGF-induced cell migration involves a cascade of signalling events, including activation of Rac1, generation of ROS and subsequent activation of PI3 ketchup and PAK1.