Journal ArticleDOI
PI3K/Akt-dependent phosphorylation of GSK3β and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration.
Jiaojing Liu,Yujie Zhang,Rui Xu,Jun Du,Zhenzhen Hu,Ling Yang,Yongchang Chen,Yichao Zhu,Luo Gu +8 more
TLDR
It is demonstrated for the first time that Wnt5a promoted gastric cancer cell migration via the PI3K/Akt/GSK3β/RhoA signaling pathway.About:
This article is published in Cellular Signalling.The article was published on 2013-02-01. It has received 79 citations till now. The article focuses on the topics: RHOA & Protein kinase B.read more
Citations
More filters
Journal ArticleDOI
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
Yoku Hayakawa,Hiroshi Ariyama,Jitka Stancikova,Kosuke Sakitani,Samuel Asfaha,Bernhard W. Renz,Bernhard W. Renz,Zinaida A. Dubeykovskaya,Wataru Shibata,Hongshan Wang,Christoph B. Westphalen,Xiaowei Chen,Yoshihiro Takemoto,Woosook Kim,Shradha S. Khurana,Yagnesh Tailor,Karan Nagar,Hiroyuki Tomita,Akira Hara,Antonia R. Sepulveda,Wanda Setlik,Michael D. Gershon,Subhrajit Saha,Lei Ding,Zeli Shen,James G. Fox,Richard A. Friedman,Stephen F. Konieczny,Daniel L. Worthley,Vladimir Korinek,Timothy C. Wang +30 more
TL;DR: It is shown that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus, providing targets within the neoplastic gastric stem cell niche.
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
Yoku Hayakawa,Hiroshi Ariyama,Jitka Stancikova,Kosuke Sakitani,Samuel Asfaha,Bernhard W. Renz,Zinaida A. Dubeykovskaya,Wataru Shibata,Hongshan Wang,Christoph B. Westphalen,Xiaowei Chen,Yoshihiro Takemoto,Woosook Kim,Shradha S. Khurana,Yagnesh Tailor,Karan Nagar,Hiroyuki Tomita,Akira Hara,Antonia R. Sepulveda,Wanda Setlik,Michael D. Gershon,Subhrajit Saha,Lei Ding,Richard A. Friedman,Stephen F. Konieczny,Daniel L. Worthley,Vladimir Korinek,Timothy C. Wang,Zeli Shen,James G. Fox +29 more
TL;DR: In this article, the authors proposed a new method for cancer drug discovery based on protein-protein interactions, and obtained grants from the National Institutes of Health (U.S.) (Grants 54CA126513, R01CA093405, R1CA120979, and R1DK052778).
Journal ArticleDOI
The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma
Tasuku Matsuoka,Masakazu Yashiro +1 more
TL;DR: Improved knowledge of the PI3K/Akt/mTOR pathway in gastric carcinoma will be useful in understanding the mechanisms of tumor development and for identifying ideal targets of anticancer therapy for gastric cancer.
Journal ArticleDOI
WNT-5A: Signaling and functions in health and disease
Kuldeep Kumawat,Reinoud Gosens +1 more
TL;DR: WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis and is associated with several human pathologies such as cancer, fibrosis, and inflammation.
Journal ArticleDOI
Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling
Nicolas Aznar,Krishna Midde,Ying Dunkel,Inmaculada Lopez-Sanchez,Yelena Pavlova,Arthur Marivin,Jorge Barbazan,Fiona Murray,Ulrich Nitsche,Klaus-Peter Janssen,Karl Willert,Ajay Goel,Miguel Abal,Mikel Garcia-Marcos,Pradipta Ghosh +14 more
TL;DR: Daple activates Gαi and enhances non-canonical Wnt signaling by FZDRs, and its dysregulation can impact both tumor initiation and progression to metastasis.
References
More filters
Journal ArticleDOI
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
TL;DR: It is shown that agents which prevent the activation of both MAPKAP kinase-1 and p70S6k by insulin in vivo do not block the phosphorylation and inhibition of GSK3, and it is demonstrated that PKB is the product of the proto-oncogene protein kinase B (PKB, also known as Akt/RAC).
Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
Journal ArticleDOI
Molecular classification of cutaneous malignant melanoma by gene expression profiling
M. Bittner,Paul S. Meltzer,Yi Chen,Yong-hui Jiang,E. A. Seftor,Mary J.C. Hendrix,Michael D. Radmacher,Richard M. Simon,Zohar Yakhini,Amir Ben-Dor,Amir Ben-Dor,Nick Sampas,Edward R. Dougherty,Ena Wang,Francesco M. Marincola,C. Gooden,John Lueders,Arthur A. Glatfelter,P.C.A. Pollock,John D. Carpten,E. Gillanders,D. Leja,K. Dietrich,Christian Beaudry,Michael E. Berens,David S. Alberts,Vernon K. Sondak,Nicholas K. Hayward,J.M. Trent +28 more
TL;DR: Many genes underlying the classification of this subset of melanomas are differentially regulated in invasive melanomas that form primitive tubular networks in vitro, a feature of some highly aggressive metastatic melanomas.
Journal ArticleDOI
Wnt signalling and its impact on development and cancer
TL;DR: A Timeline of crucial discoveries about the components and functions of this essential pathway is presented.