Z
Zhi Chen
Researcher at Åbo Akademi University
Publications - 34
Citations - 4331
Zhi Chen is an academic researcher from Åbo Akademi University. The author has contributed to research in topics: Cellular differentiation & Gene. The author has an hindex of 19, co-authored 33 publications receiving 3996 citations. Previous affiliations of Zhi Chen include University of Turku & University of Oulu.
Papers
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Journal ArticleDOI
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Arian Laurence,Cristina M. Tato,Todd S. Davidson,Yuka Kanno,Zhi Chen,Zhengju Yao,Rebecca Blank,Françoise Meylan,Richard M. Siegel,Lothar Hennighausen,Ethan M. Shevach,John J. O'Shea +11 more
TL;DR: It is demonstrated that in addition to the promotion of activation-induced cell death of lymphocytes and the generation of Treg cells, inhibition of Th17 polarization appears to be an important function of IL-2.
Journal ArticleDOI
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
Zhi Chen,Arian Laurence,Yuka Kanno,Margit Pacher-Zavisin,Bing Mei Zhu,Cristina M. Tato,Akihiko Yoshimura,Lothar Hennighausen,John J. O'Shea +8 more
TL;DR: It is concluded that Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of Th17 differentiation.
Journal ArticleDOI
Distinct regulation of interleukin‐17 in human T helper lymphocytes
TL;DR: The present data demonstrate the differential regulation of IL-17 and RORgammat expression in human CD4+ T cells compared with murine cells, which may have important implications in the pathogenesis of human autoimmunity as compared with mouse models.
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Th17 cells: a new fate for differentiating helper T cells.
TL;DR: Designated Th17 cells, a new lineage of helper T cells, selectively produces proinflammatory cytokines including IL-17, IL-21, and IL-22 and may be beneficial for the treatment of inflammatory and autoimmune diseases.
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Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation
TL;DR: The discovery of a new lineage of helper T cells that selectively produces interleukin (IL)-17 has provided exciting new insights into immunoregulation, host defense and the pathogenesis of autoimmune diseases.