Yuka Kanno

TL;DR: It is demonstrated that in addition to the promotion of activation-induced cell death of lymphocytes and the generation of Treg cells, inhibition of Th17 polarization appears to be an important function of IL-2.

TL;DR: In this article, the authors show that T(H)17 differentiation can occur in the absence of TGF-β signalling, without the need of transforming growth factor (TGF)-β1.

TL;DR: Although modifications of signature-cytokine genes (Ifng, Il4, and Il17) partially conform to the expectation of lineage commitment, genes encoding transcription factors like Tbx21 exhibit a broad spectrum of epigenetic states, consistent with the demonstrated T-bet and interferon-gamma induction in nTreg cells.

TL;DR: Ex vivo T cells from subjects with HIES failed to produce IL-17, but not IL-2, tumour-necrosis factor or interferon-γ, on mitogenic stimulation with staphylococcal enterotoxin B or on antigenic stimulation with Candida albicans or streptokinase, which is consistent with a crucial role for STAT3 signalling in the generation of TH17 cells.

TL;DR: The biology of JAKs is discussed from a translational perspective, focusing on recent insights from clinical trials, the development of novel agents and the use of jakinibs in a spectrum of immune and inflammatory diseases.