Zhike Zi

TL;DR: The author discusses the advantages and disadvantages of different sensitivity analysis methods, how to choose a proper sensitivity analysis approach, the available sensitivity analysis tools for systems biology models and the caveats in the interpretation of sensitivity analysis results.

TL;DR: Recent progress in understanding TGF‐β biology is reviewed using integration of mathematical modeling and quantitative experimental analysis and these studies reveal many interesting dynamics of T GF‐β signaling and how cells quantitatively decode variable doses of TGF-β stimulation.

TL;DR: A recent mathematical model of interferon gamma induced Janus kinase‐signal transducers and activators of transcription (JAK‐STAT) signaling pathway is investigated by applying multi‐parametric sensitivity analysis based on simultaneous variation of the parameter values and it is found that suppressor of cytokine signaling‐1, nuclear phosphatases, cytoplasmic STAT1, and the corresponding reaction steps are sensitive perturbation points of this pathway.

TL;DR: It is discovered that cells respond differently to continuous and pulsating TGF‐β stimulation, and long‐term switch‐like signaling responses in the T GF‐β pathway might be critical for cell fate determination.

TL;DR: A constraint-based modeling method is proposed to build a comprehensive mathematical model for the Smad dependent TGF-β signaling pathway by fitting the experimental data and incorporating the qualitative constraints from the experimental analysis, which indicates that the signal response to T GF-β is regulated by the balance between clathrin dependent endocytosis and non-clathrin mediated endocyTosis.