Z
Zhimin Li
Researcher at Mayo Clinic
Publications - 8
Citations - 158
Zhimin Li is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Diffuse large B-cell lymphoma & Lymphoma. The author has an hindex of 6, co-authored 8 publications receiving 113 citations.
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Journal ArticleDOI
Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models
Zhimin Li,Yushi Qiu,David Personett,Peng Huang,Brandy Edenfield,Jason Katz,Darius Babusis,Yang Tang,Michael A. Shirely,Mehran F. Moghaddam,John A. Copland,Han W. Tun +11 more
TL;DR: POM is a promising therapeutic agent for CNS lymphoma with excellent CNS penetration, significant preclinical therapeutic activity, and a major impact on the tumor microenvironment.
Journal ArticleDOI
Immune checkpoint inhibition by anti-PDCD1 (anti-PD1) monoclonal antibody has significant therapeutic activity against central nervous system lymphoma in an immunocompetent preclinical model
Yushi Qiu,Zhimin Li,Frederic Pouzoulet,Prakash Vishnu,John A. Copland,Keith L. Knutson,Carole Soussain,Han W. Tun +7 more
TL;DR: This study aims to enhance the classification system of the severity of this disorder by using the free a-Hb pool in the scoring system to diagnose, prognosis determination, and treatment monitoring of patients with b-thal.
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Pomalidomide Alters Pancreatic Macrophage Populations to Generate an Immune-Responsive Environment at Precancerous and Cancerous Lesions
Ligia I. Bastea,Geou Yarh Liou,Geou Yarh Liou,Veethika Pandey,Alicia K. Fleming,Christina A. von Roemeling,Heike Doeppler,Zhimin Li,Yushi Qiu,Brandy Edenfield,John A. Copland,Han W. Tun,Peter Storz +12 more
TL;DR: It is shown that the immunomodulatory agent pomalidomide depletes pancreatic lesion areas of alternatively activated macrophage populations, providing the means to turn the microenvironment from immunosuppressive to immune-responsive.
Journal Article
Primary central nervous system B cell lymphoma with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma.
Liuyan Jiang,Zhimin Li,Laura Finn,David A Personnet,Brandy Edenfield,James M. Foran,Kurt A. Jaeckle,Ronald Reimer,David M. Menke,Rhett P. Ketterling,Han W. Tun +10 more
TL;DR: This case shows that a DLBCL/BL can manifest in the CNS alone without any systemic involvement and is characterized by a very aggressive clinical course, and a widespread multifocal involvement of the CNS.
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Osteopontin is a multi-faceted pro-tumorigenic driver for central nervous system lymphoma
Qiu Yushi,Zhimin Li,Christina A. von Roemeling,Heike Doeppler,Laura A. Marlow,Betty Y.S. Kim,Derek C. Radisky,Peter Storz,John A. Copland,Han W. Tun +9 more
TL;DR: The results implicate OPN as a candidate for development of targeted therapy for patients with PCNSL and identify NF-κB-mediated induction of matrix metalloproteinase-8 (MMP-8) as a specific feature of OPN-mediated tissue invasion.