Z
Zhiwen Xu
Researcher at Hong Kong University of Science and Technology
Publications - 32
Citations - 785
Zhiwen Xu is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: GABAA receptor & Transfer RNA. The author has an hindex of 17, co-authored 30 publications receiving 686 citations. Previous affiliations of Zhiwen Xu include Queen's University & Johns Hopkins University.
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Journal ArticleDOI
Human tRNA synthetase catalytic nulls with diverse functions
Wing-Sze Lo,Elisabeth Gardiner,Zhiwen Xu,Zhiwen Xu,Ching-Fun Lau,Ching-Fun Lau,Feng Wang,Feng Wang,Jie J. Zhou,Jie J. Zhou,John D. Mendlein,Leslie A. Nangle,Kyle P. Chiang,Xiang-Lei Yang,Kin Fai Au,Wing Hung Wong,Min Guo,Mingjie Zhang,Paul Schimmel,Paul Schimmel +19 more
TL;DR: It is suggested that splice variants with nonenzymatic functions may be more general, as evidenced by recent findings of other catalytically inactive splice-variant enzymes.
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GABAA receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone
TL;DR: 6-Hydroxyflavone is identified as a promising drug candidate for the treatment of anxiety-like disorders by showing that 6HF partially potentiated GABA-induced currents in native GABA(A) receptors expressed in cortical neurons via BZ site, as the enhancement was blocked by the antagonist flumazenil.
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GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin
TL;DR: An underlying mechanism for the selective anxiolytic profile of baicalin was revealed, suggesting alpha2- and alpha3-containing subtypes were important drug targets for flavonoid-based anxioleytics.
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Two isoforms of GABA(A) receptor beta2 subunit with different electrophysiological properties: Differential expression and genotypical correlations in schizophrenia.
Cunyou Zhao,Zhiwen Xu,Jianhuan Chen,Zhiliang Yu,Ka Lok Tong,Wing-Sze Lo,Frank Wing Pun,Siu Kin Ng,Shui Ying Tsang,Hong Xue +9 more
TL;DR: Genotype-dependent expression of the alternatively spliced isoforms of GABAA receptor β2 subunit gives rise to electrophysiological consequences that could play an important role in the pathogenesis mechanism of schizophrenia.
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The Evolution of GABAA Receptor–Like Genes
TL;DR: The results strongly indicate that such a gene pair originally existed in the bilaterian ancestor from which all 3 phyla evolved and suggest that the extant GABR clusters arose from an ancestral alpha-beta subunit gene pair that gave rise to the extant gabr clusters.