K
Kin Fai Au
Researcher at Ohio State University
Publications - 44
Citations - 5622
Kin Fai Au is an academic researcher from Ohio State University. The author has contributed to research in topics: Gene & Transcriptome. The author has an hindex of 21, co-authored 39 publications receiving 4429 citations. Previous affiliations of Kin Fai Au include Huazhong University of Science and Technology & Stanford University.
Papers
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Journal ArticleDOI
PacBio Sequencing and Its Applications.
Anthony Rhoads,Kin Fai Au +1 more
TL;DR: Single-molecule, real-time sequencing developed by Pacific BioSciences offers longer read lengths than the second-generation sequencing technologies, making it well-suited for unsolved problems in genome, transcriptome, and epigenetics research.
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Comprehensive comparison of Pacific Biosciences and Oxford Nanopore Technologies and their applications to transcriptome analysis.
Jason L. Weirather,Mariateresa de Cesare,Yunhao Wang,Yunhao Wang,Paolo Piazza,Vittorio Sebastiano,Xiu-Jie Wang,David Buck,Kin Fai Au +8 more
TL;DR: Both PacBio and ONT sequencing are suitable for full-length single-molecule transcriptome analysis as this first use of ONT reads in a Hybrid-Seq analysis has shown.
Journal ArticleDOI
Detection of splice junctions from paired-end RNA-seq data by SpliceMap
TL;DR: A computational method, SpliceMap, to detect splice junctions from RNA-seq data is presented, which does not depend on any existing annotation of gene structures and is capable of finding novel splicing junctions with high sensitivity and specificity.
Journal ArticleDOI
Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming
Jieun Lee,Nazish Sayed,Arwen L. Hunter,Kin Fai Au,Wing Hung Wong,Edward S. Mocarski,Renee A. Reijo Pera,Eduard Yakubov,John P. Cooke +8 more
TL;DR: In gain- and loss-of-function studies, it is found that the toll-like receptor 3 (TLR3) pathway enables efficient induction of pluripotency by viral or mmRNA approaches.
Journal ArticleDOI
Improving PacBio Long Read Accuracy by Short Read Alignment
TL;DR: A computational method, LSC, to perform error correction of TGS long reads (LR) by SGS short reads (SR) by applying a homopolymer compression (HC) transformation strategy to increase the sensitivity of SR-LR alignment without scarifying alignment accuracy is presented.