Z
Zhixiang Xu
Researcher at Southern University of Science and Technology
Publications - 17
Citations - 3054
Zhixiang Xu is an academic researcher from Southern University of Science and Technology. The author has contributed to research in topics: Medicine & Virus. The author has an hindex of 6, co-authored 11 publications receiving 2381 citations.
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Journal ArticleDOI
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma.
Chenguang Shen,Zhaoqin Wang,Fang Zhao,Yang Yang,Jinxiu Li,Jing Yuan,Fuxiang Wang,Delin Li,Delin Li,Minghui Yang,Li Xing,Jinli Wei,Haixia Xiao,Haixia Xiao,Yan Yang,Jiuxin Qu,Ling Qing,Li Chen,Zhixiang Xu,Ling Peng,Yanjie Li,Haixia Zheng,Feng Chen,Kun Huang,Yujing Jiang,Dongjing Liu,Zheng Zhang,Yingxia Liu,Lei Liu +28 more
TL;DR: In this preliminary uncontrolled case series of 5 critically ill patients with COVID-19 and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status, and these observations require evaluation in clinical trials.
Journal ArticleDOI
Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19.
Yang Yang,Chenguang Shen,Jinxiu Li,Jing Yuan,Jinli Wei,Fengmin Huang,Fuxiang Wang,Guobao Li,Yanjie Li,Li Xing,Ling Peng,Minghui Yang,Mengli Cao,Haixia Zheng,Weibo Wu,Rongrong Zou,Delin Li,Zhixiang Xu,Haiyan Wang,Mingxia Zhang,Zheng Zhang,George F. Gao,Chengyu Jiang,Lei Liu,Yingxia Liu +24 more
TL;DR: These findings add to the understanding of the immunopathologic mechanisms of SARS-CoV-2 infection, and provide potential therapeutic targets and strategies.
Posted ContentDOI
Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome
Yang Yang,Chenguang Shen,Jinxiu Li,Jing Yuan,Minghui Yang,Fuxiang Wang,Guobao Li,Yanjie Li,Li Xing,Ling Peng,Jinli Wei,Mengli Cao,Haixia Zheng,Weibo Wu,Rongrong Zou,Delin Li,Zhixiang Xu,Haiyan Wang,Mingxia Zhang,Zheng Zhang,Lei Liu,Yingxia Liu +21 more
TL;DR: Serial detection of IP-10, MCP-3 and IL-1ra in 14 severe cases showed that the continuous high levels of these cytokines were associated with disease deterioration and fatal outcome of COVID-19, adding to the understanding of the immunopathologic mechanisms of SARS-CoV-2 infection.
Journal ArticleDOI
Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury
Yingxia Liu,Cong Zhang,Cong Zhang,Fengming Huang,Yang Yang,Fuxiang Wang,Jing Yuan,Zheng Zhang,Yuhao Qin,Li Xiaoyun,Dandan Zhao,Shunwang Li,Shuguang Tan,Zhaoqin Wang,Jinxiu Li,Chenguang Shen,Jianming Li,Ling Peng,Weibo Wu,Mengli Cao,Li Xing,Zhixiang Xu,Li Chen,Cong-Zhao Zhou,William J. Liu,Lei Liu,Chengyu Jiang +26 more
TL;DR: It is suggested that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of which could be potential biomarkers of disease severity of2019-n coV infections.
Journal ArticleDOI
Longitudinal analysis of antibody dynamics in COVID-19 convalescents reveals neutralizing responses up to 16 months after infection
Yang Yang,Minghui Yang,Yun Peng,Yanhua Liang,Jinli Wei,Li Xing,Li Guo,Xiaohe Li,Jie Li,Jun Wang,Mian-sha Li,Zhixiang Xu,Ming-Xiang Zhang,Fu-Sheng Wang,Yi Shi,Jing Yuan,Yingxia Liu +16 more
TL;DR: In this article , the authors measured nAb titres across 411 sequential plasma samples collected during 1-480 d after illness onset or laboratory confirmation (d.a.o.) from 214 COVID-19 convalescents, covering the clinical spectrum of disease and without additional exposure history after recovery or vaccination against SARS-CoV-2.