Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19.
Yang Yang,Chenguang Shen,Jinxiu Li,Jing Yuan,Jinli Wei,Fengmin Huang,Fuxiang Wang,Guobao Li,Yanjie Li,Li Xing,Ling Peng,Minghui Yang,Mengli Cao,Haixia Zheng,Weibo Wu,Rongrong Zou,Delin Li,Zhixiang Xu,Haiyan Wang,Mingxia Zhang,Zheng Zhang,George F. Gao,Chengyu Jiang,Lei Liu,Yingxia Liu +24 more
TLDR
These findings add to the understanding of the immunopathologic mechanisms of SARS-CoV-2 infection, and provide potential therapeutic targets and strategies.Abstract:
Background The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 was first reported in Wuhan, December 2019, and continuously poses a serious threat to public health, highlighting the urgent need of identifying biomarkers for disease severity and progression. Objective We sought to identify biomarkers for disease severity and progression of COVID-19. Methods Forty-eight cytokines in the plasma samples from 50 COVID-19 cases including 11 critically ill, 25 severe, and 14 moderate patients were measured and analyzed in combination with clinical data. Results Levels of 14 cytokines were found to be significantly elevated in COVID-19 cases and showed different expression profiles in patients with different disease severity. Moreover, expression levels of IFN-γ–induced protein 10, monocyte chemotactic protein-3, hepatocyte growth factor, monokine-induced gamma IFN, and macrophage inflammatory protein 1 alpha, which were shown to be highly associated with disease severity during disease progression, were remarkably higher in critically ill patients, followed by severe and then the moderate patients. Serial detection of the 5 cytokines in 16 cases showed that continuously high levels were associated with deteriorated progression of disease and fatal outcome. Furthermore, IFN-γ–induced protein 10 and monocyte chemotactic protein-3 were excellent predictors for the progression of COVID-19, and the combination of the 2 cytokines showed the biggest area under the curve of the receiver-operating characteristics calculations with a value of 0.99. Conclusions In this study, we report biomarkers that are highly associated with disease severity and progression of COVID-19. These findings add to our understanding of the immunopathologic mechanisms of severe acute respiratory syndrome coronavirus 2 infection, and provide potential therapeutic targets and strategies.read more
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Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal
Laure Wynants,Laure Wynants,Ben Van Calster,Ben Van Calster,Gary S. Collins,Gary S. Collins,Richard D Riley,Georg Heinze,Ewoud Schuit,Marc J.M. Bonten,Darren Dahly,Johanna A A G Damen,Thomas P. A. Debray,Valentijn M.T. de Jong,Maarten De Vos,Paula Dhiman,Paula Dhiman,Maria C Haller,Michael O. Harhay,Liesbet Henckaerts,Pauline Heus,Michael Kammer,Nina Kreuzberger,Anna Lohmann,Kim Luijken,Jie Ma,Glen P. Martin,David J. McLernon,Constanza L Andaur Navarro,Johannes B. Reitsma,Jamie C. Sergeant,Chunhu Shi,Nicole Skoetz,Luc J.M. Smits,Kym I E Snell,Matthew Sperrin,René Spijker,René Spijker,Ewout W. Steyerberg,Toshihiko Takada,Ioanna Tzoulaki,Ioanna Tzoulaki,Sander M. J. van Kuijk,Bas C T van Bussel,Bas C T van Bussel,Iwan C. C. van der Horst,Florien S. van Royen,Jan Y Verbakel,Jan Y Verbakel,Christine Wallisch,Christine Wallisch,Jack Wilkinson,Robert Wolff,Lotty Hooft,Karel G.M. Moons,Maarten van Smeden +55 more
TL;DR: Proposed models for covid-19 are poorly reported, at high risk of bias, and their reported performance is probably optimistic, according to a review of published and preprint reports.
Journal ArticleDOI
Immunology of COVID-19: Current State of the Science.
Nicolas Vabret,Graham J. Britton,Conor Gruber,Samarth Hegde,Joel Kim,Maria Kuksin,Rachel Levantovsky,Louise Malle,Alvaro Moreira,Matthew D. Park,Luisanna Pia,Emma Risson,Miriam Saffern,Bérengère Salomé,Myvizhi Esai Selvan,Matthew P. Spindler,Jessica Tan,Verena van der Heide,Jill Gregory,Konstantina Alexandropoulos,Nina Bhardwaj,Brian D. Brown,Benjamin Greenbaum,Zeynep H. Gümüş,Dirk Homann,Amir Horowitz,Alice O. Kamphorst,Maria A. Curotto de Lafaille,Saurabh Mehandru,Miriam Merad,Robert M. Samstein,Manasi Agrawal,Mark Aleynick,Meriem Belabed,Matthew Brown,Maria Casanova-Acebes,Jovani Catalan,Monica Centa,Andrew Charap,Andrew K Chan,Steven T. Chen,Jonathan Chung,Cansu Cimen Bozkus,Evan Cody,Francesca Cossarini,Erica Dalla,Nicolas F. Fernandez,John A. Grout,Dan Fu Ruan,Pauline Hamon,Etienne Humblin,Divya Jha,Julia Kodysh,Andrew Leader,Matthew Lin,Katherine E. Lindblad,Daniel Lozano-Ojalvo,Gabrielle Lubitz,Assaf Magen,Zafar Mahmood,Gustavo Martinez-Delgado,Jaime Mateus-Tique,Elliot Meritt,Chang Moon,Justine Noel,Timothy O'Donnell,Miyo Ota,Tamar Plitt,Venu Pothula,Jamie Redes,Ivan Reyes Torres,Mark P. Roberto,Alfonso R. Sanchez-Paulete,Joan Shang,Alessandra Soares Schanoski,Maria Suprun,Michelle Tran,Natalie Vaninov,C. Matthias Wilk,Julio A. Aguirre-Ghiso,Dusan Bogunovic,Judy H. Cho,Jeremiah J. Faith,Emilie K. Grasset,Peter S. Heeger,Ephraim Kenigsberg,Florian Krammer,Uri Laserson +87 more
TL;DR: The current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death are summarized.
Journal ArticleDOI
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity.
Carolyn Rydyznski Moderbacher,Sydney I. Ramirez,Sydney I. Ramirez,Jennifer M. Dan,Jennifer M. Dan,Alba Grifoni,Kathryn M. Hastie,Daniela Weiskopf,Simon Bélanger,Robert K. Abbott,Christina K. Kim,Jinyong Choi,Yu Kato,Eleanor G. Crotty,Cheryl Kim,Stephen A. Rawlings,Jose Mateus,Longping V. Tse,April Frazier,Ralph S. Baric,Bjoern Peters,Jason A. Greenbaum,Erica Ollmann Saphire,Erica Ollmann Saphire,Davey M. Smith,Alessandro Sette,Alessandro Sette,Shane Crotty,Shane Crotty +28 more
TL;DR: A combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects suggested roles for both CD4 plus T cells in protective immunity in COVID-19.
Journal ArticleDOI
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.
Emma S. Winkler,Adam L. Bailey,Natasha M. Kafai,Sharmila Nair,Broc T. McCune,Jinsheng Yu,Julie M. Fox,Rita E. Chen,James T. Earnest,Shamus P. Keeler,Jon H. Ritter,Liang I. Kang,Sarah Dort,Annette Robichaud,Richard D. Head,Michael J. Holtzman,Michael S. Diamond +16 more
TL;DR: The transgenic mice expressing the human angiotensin I-converting enzyme 2 (ACE2) receptor driven by the cytokeratin-18 (K18) gene promoter are evaluated as a model of SARS-CoV-2 infection to define the basis of lung disease and test immune and antiviral-based countermeasures.
Journal ArticleDOI
Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes.
Daniel E. Leisman,Daniel E. Leisman,Daniel E. Leisman,Lukas Ronner,Lukas Ronner,Rachel Pinotti,Matthew D. Taylor,Matthew D. Taylor,Pratik Sinha,Carolyn S. Calfee,Alexandre V. Hirayama,Fiore Mastroiani,Cameron J. Turtle,Michael O. Harhay,Matthieu Legrand,Clifford S. Deutschman,Clifford S. Deutschman +16 more
TL;DR: The findings question the role of a cytokine storm in COVID-19-induced organ dysfunction and the potential role of anti-cytokine and immune-modulating treatments in patients with the disease.
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
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TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
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