Zhixiong Wang

TL;DR: The fabrication of photosensitizer-conjugated polymeric vesicles is reported, exhibiting synergistic NQO1-triggered turn-on of both near-infrared (NIR) fluorescence emission and photodynamic therapy (PDT) module, and could be successfully applied for activated NIR fluorescence imaging and tissue-specific PDT under both cellular and in vivo conditions.

TL;DR: Photosensitizer-free polymeric nanocapsules loaded with nitric oxide (NO) donors, namely NO-NCPs, formulated from NIR light-absorbable amphiphilic polymers and a NO-releasing donor, DETA NONOate are reported, which greatly promotes mitochondrial damage and DNA fragmentation to initiate programmed cancer cell death.

TL;DR: A large amount of biofilm hosted in implanted materials and medical devices is a serious threat for modern medical system and needs to be addressed.

TL;DR: In vitro and in vivo analyses demonstrate that CPNs can efficiently overcome cisplatin resistance by current collaborative modalities, and the rational design of cocktail polyprodrug provides a confined space to pump out NO and ONOO− efficiently.

TL;DR: P pulsed microwave-pumped biocompatible polyarginine is promising for drug-free precision theranostics without any detectable side effects, and the deep penetration potency of microwave makes it potentially able to treat deep-seated diseases in future biomedicine.